Nucleolar pre-ribosomal-associated protein 1 (URB1)
The protein contains 2271 amino acids for an estimated molecular weight of 254389 Da.
No function (updated: Oct. 10, 2018)
Protein identification was indicated in the following studies:
Methods
The following articles were analysed to gather the proteome content of erythrocytes.
The gene or protein list provided in the studies were processed using the ID mapping API of Uniprot in September 2018. The number of proteins identified and mapped without ambiguity in these studies is indicated below.
Only Swiss-Prot entries (reviewed) were considered for protein evidence assignation.
| Publication | Identification 1 | Uniprot mapping 2 | Not mapped / Obsolete | TrEMBL | Swiss-Prot |
|---|---|---|---|---|---|
| Goodman (2013) | 2289 (gene list) | 2278 | 53 | 20599 | 2269 |
| Lange (2014) | 1234 | 1234 | 7 | 28 | 1224 |
| Hegedus (2015) | 2638 | 2622 | 0 | 235 | 2387 |
| Wilson (2016) | 1658 | 1528 | 170 | 291 | 1068 |
| d'Alessandro (2017) | 1826 | 1817 | 2 | 0 | 1815 |
| Bryk (2017) | 2090 | 2060 | 10 | 108 | 1942 |
| Chu (2018) | 1853 | 1804 | 55 | 362 | 1387 |
1 as available in the article and/or in supplementary material
2 uniprot mapping returns all protein isoforms as one entry
The compilation of older studies can be retrieved from the Red Blood Cell Collection database.
The data and differentiation stages presented below come from the proteomic study and analysis performed by our partners of the GReX consortium, more details are available in their published work.
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| Variant | Description |
|---|---|
| dbSNP:rs3761342 | |
| dbSNP:rs762225 |
The reference OMIM entry for this protein is 608865
Npa1, yeast, homolog of
Npa1
Chromosome 21 open reading frame 108; c21orf108
Kiaa0539
CLONING
By sequencing clones obtained from a size-fractionated brain cDNA library, Nagase et al. (1998) cloned NPA1, which they designated KIAA0539. The 3-prime UTR contains Alu sequences and other repetitive elements. RT-PCR detected highest NPA1 expression in kidney, followed by liver, skeletal muscle, prostate, ovary, heart, brain, placenta, lung, testis, pancreas, and spleen. Little to no expression was detected in thymus and small intestine. By searching for sequences similar to yeast Npa1, Dez et al. (2004) identified human NPA1, which encodes a nucleolar protein containing 2,248 amino acids.GENE FUNCTION
Dez et al. (2004) found that Npa1 accumulated in the immediate vicinity of the dense fibrillar component of the nucleolus in yeast. Npa1 was predominantly associated with the 27SA2 pre-rRNA, the RNA component of the earliest pre-60S ribosomal particles. Absence of Npa1 perturbed the pre-rRNA processing pathway leading to 5.8S and 25S rRNA. Npa1 interacted with 8 putative helicases as well as with other nucleolar factors.MAPPING
By radiation hybrid analysis, Nagase et al. (1998) mapped the NPA1 gene to chromosome 21. ... More on the omim web site
June 30, 2020: Protein entry updated
Automatic update: OMIM entry 608865 was added.
Oct. 19, 2018: Additional information
Initial protein addition to the database. This entry was referenced in Bryk and co-workers. (2017).