Keratin, type II cytoskeletal 78 (KRT78)
The protein contains 520 amino acids for an estimated molecular weight of 56866 Da.
No function (updated: Sept. 12, 2018)
Protein identification was indicated in the following studies:
Methods
The following articles were analysed to gather the proteome content of erythrocytes.
The gene or protein list provided in the studies were processed using the ID mapping API of Uniprot in September 2018. The number of proteins identified and mapped without ambiguity in these studies is indicated below.
Only Swiss-Prot entries (reviewed) were considered for protein evidence assignation.
| Publication | Identification 1 | Uniprot mapping 2 | Not mapped / Obsolete | TrEMBL | Swiss-Prot |
|---|---|---|---|---|---|
| Goodman (2013) | 2289 (gene list) | 2278 | 53 | 20599 | 2269 |
| Lange (2014) | 1234 | 1234 | 7 | 28 | 1224 |
| Hegedus (2015) | 2638 | 2622 | 0 | 235 | 2387 |
| Wilson (2016) | 1658 | 1528 | 170 | 291 | 1068 |
| d'Alessandro (2017) | 1826 | 1817 | 2 | 0 | 1815 |
| Bryk (2017) | 2090 | 2060 | 10 | 108 | 1942 |
| Chu (2018) | 1853 | 1804 | 55 | 362 | 1387 |
1 as available in the article and/or in supplementary material
2 uniprot mapping returns all protein isoforms as one entry
The compilation of older studies can be retrieved from the Red Blood Cell Collection database.
The data and differentiation stages presented below come from the proteomic study and analysis performed by our partners of the GReX consortium, more details are available in their published work.
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| Variant | Description |
|---|---|
| dbSNP:rs11170289 | |
| dbSNP:rs2013335 | |
| dbSNP:rs2682343 | |
| dbSNP:rs10876360 |
No binding partner found
The reference OMIM entry for this protein is 611159
Keratin 78, type ii; krt78
K78
Kb40
Keratin 5b; k5b
DESCRIPTION
Keratins, such as KRT78, are filament proteins that make up one of the major structural fibers of epithelial cells (Rogers et al., 2005).CLONING
Using database analysis to identify keratin genes within the type II keratin gene domain on chromosome 12, Rogers et al. (2005) identified KRT78, which they called K5B. The deduced 520-amino acid protein has a calculated molecular mass of 56.8 kD. Like other type II keratins, K5B has N- and C-terminal domains and a central rod domain consisting of 4 alpha-helical regions separated by 3 non-helical linker sequences. Northern blot analysis detected expression of a 1.9-kb K5B transcript in tongue, but not in skin or in any other tissues or organs examined.MAPPING
By genomic sequence analysis, Rogers et al. (2005) mapped the KRT78 gene to chromosome 12q13.13. ... More on the omim web site
Oct. 20, 2018: Protein entry updated
Automatic update: OMIM entry 611159 was added.
Oct. 19, 2018: Additional information
Initial protein addition to the database. This entry was referenced in Bryk and co-workers. (2017).