Keratin, type II cytoskeletal 80 (KRT80)

The protein contains 452 amino acids for an estimated molecular weight of 50525 Da.

 

No function (updated: Oct. 10, 2018)

Protein identification was indicated in the following studies:

  1. D'Alessandro and co-workers. (2017) Red blood cell proteomics update: is there more to discover? Blood Transfus. 15(2), 182-187.

Methods

The following articles were analysed to gather the proteome content of erythrocytes.

The gene or protein list provided in the studies were processed using the ID mapping API of Uniprot in September 2018. The number of proteins identified and mapped without ambiguity in these studies is indicated below.
Only Swiss-Prot entries (reviewed) were considered for protein evidence assignation.

PublicationIdentification 1Uniprot mapping 2Not mapped /
Obsolete		TrEMBLSwiss-Prot
Goodman (2013)2289 (gene list)227853205992269
Lange (2014)123412347281224
Hegedus (2015)2638262202352387
Wilson (2016)165815281702911068
d'Alessandro (2017)18261817201815
Bryk (2017)20902060101081942
Chu (2018)18531804553621387

1 as available in the article and/or in supplementary material
2 uniprot mapping returns all protein isoforms as one entry

The compilation of older studies can be retrieved from the Red Blood Cell Collection database.

The data and differentiation stages presented below come from the proteomic study and analysis performed by our partners of the GReX consortium, more details are available in their published work.

No sequence conservation computed yet.
Protein sequence (FASTA)
Protein coevolution profile (FreeContact)
Multiple Sequence Alignment (Muscle)

Interpro domains
Total structural coverage: 32%
Model score: 0
No model available.

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VariantDescription
dbSNP:rs35725856

No binding partner found

The reference OMIM entry for this protein is 611161

Keratin 80, type ii; krt80
K80
Keratin b20; kb20

DESCRIPTION

Keratins, such as KRT80, are filament proteins that make up one of the major structural fibers of epithelial cells (Rogers et al., 2005).

CLONING

Using database analysis to identify keratin genes within the type II keratin gene domain on chromosome 12, Rogers et al. (2005) identified KRT80, which they called KB20. The deduced 452-amino acid protein has a calculated molecular mass of 50.5 kD. Like other type II keratins, KB20 has N- and C-terminal domains and a central rod domain consisting of 4 alpha-helical regions separated by 3 nonhelical linker sequences. Northern blot analysis detected weak expression of a 3.5-kb KB20 transcript in tongue, but not skin or in any other tissues or organs examined.

MAPPING

By genomic sequence analysis, Rogers et al. (2005) mapped the KRT80 gene to chromosome 12q13.13. ... More on the omim web site

Subscribe to this protein entry history

Oct. 20, 2018: Protein entry updated
Automatic update: OMIM entry 611161 was added.

Oct. 19, 2018: Additional information
Initial protein addition to the database. This entry was referenced in Bryk and co-workers. (2017).