Introduction
Transmembrane proteins are essential proteins implicated in many major biological and pathological processes. Nonetheless, due to experimental difficulties, the number of avalaible membrane protein structures remains limited. Hence, building and assessment of protein structural models are complicated tasks.
HPMscore is a dedicated tool designed to score membrane protein structural models.
HPMscore was extensively tested using the HOMEP2 database as a reference; it proved its efficiency being more discriminative than the other available tools.
The principle of the algorithm is detailed in the documentation page.
HPMscore (list of models in an archive)
Upload one archive containing all your pdb files of containing the models of one protein. The archive must be in zip or tar.gz format.
Each PDB file will be processed to keep atom coordinates, only the first chain will be analyzed. Please be sure to have valid pdb files prior the upload.
Click on the DEMO button for a demonstration of the web service for each input.
HPMscore (individual models)
Upload individual PDB files using the upload boxes below (as much as required).
Press the "Get HPMscore !" button to process your query.