Inter-alpha-trypsin inhibitor heavy chain H2 (ITIH2)
The protein contains 946 amino acids for an estimated molecular weight of 106463 Da.
May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes. (updated: Oct. 10, 2018)
Protein identification was indicated in the following studies:
Methods
The following articles were analysed to gather the proteome content of erythrocytes.
The gene or protein list provided in the studies were processed using the ID mapping API of Uniprot in September 2018. The number of proteins identified and mapped without ambiguity in these studies is indicated below.
Only Swiss-Prot entries (reviewed) were considered for protein evidence assignation.
| Publication | Identification 1 | Uniprot mapping 2 | Not mapped / Obsolete | TrEMBL | Swiss-Prot |
|---|---|---|---|---|---|
| Goodman (2013) | 2289 (gene list) | 2278 | 53 | 20599 | 2269 |
| Lange (2014) | 1234 | 1234 | 7 | 28 | 1224 |
| Hegedus (2015) | 2638 | 2622 | 0 | 235 | 2387 |
| Wilson (2016) | 1658 | 1528 | 170 | 291 | 1068 |
| d'Alessandro (2017) | 1826 | 1817 | 2 | 0 | 1815 |
| Bryk (2017) | 2090 | 2060 | 10 | 108 | 1942 |
| Chu (2018) | 1853 | 1804 | 55 | 362 | 1387 |
1 as available in the article and/or in supplementary material
2 uniprot mapping returns all protein isoforms as one entry
The compilation of older studies can be retrieved from the Red Blood Cell Collection database.
The data and differentiation stages presented below come from the proteomic study and analysis performed by our partners of the GReX consortium, more details are available in their published work.
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| Variant | Description |
|---|---|
| dbSNP:rs7075296 | |
| dbSNP:rs7084817 | |
| dbSNP:rs3740217 |
No binding partner found
Biological Process
Cellular protein metabolic process
Hyaluronan metabolic process
Post-translational protein modification
The reference OMIM entry for this protein is 146640
Inter-alpha-trypsin inhibitor, heavy chain 2; itih2
DESCRIPTION
The inter-alpha-trypsin inhibitors (ITI) are a family of structurally related plasma serine protease inhibitors involved in extracellular matrix stabilization and in prevention of tumor metastasis. The ITI family contains multiple proteins made up of a light chain (see 176870) and a variable number of heavy chains (Salier et al., 1987; Himmelfarb et al., 2004).CLONING
By screening a liver expression library with antibodies against ITI chains, Salier et al. (1987) isolated a partial cDNA encoding an ITI heavy chain. Diarra-Mehrpour et al. (1989) analyzed the in vitro translation product of liver mRNAs hybrid-selected by this partial cDNA, lambda-HUHITI(9+33), and determined that it encoded the H2 (ITIH2) heavy chain. Enghild et al. (1989) found that one ITI member is composed of the mature ITIH1 (HC1; 147270) and ITIH2 (HC2) heavy chains and a 30-kD subunit. Bost et al. (1993) stated that the 30-kD subunit is bikunin (see 176870).MAPPING
By in situ hybridization, Diarra-Mehrpour et al. (1989) mapped the ITIH2 gene to 10p15. With a restriction fragment length variant (RFLV) in or near the equivalent of the human ITIH2 gene in the study of interspecific backcrosses between C57BL and Mus spretus, Salier et al. (1992) mapped the mouse counterpart (Intin-2) to the centromeric region of chromosome 2. ... More on the omim web site
Nov. 17, 2018: Protein entry updated
Automatic update: OMIM entry 146640 was added.
Oct. 19, 2018: Additional information
Initial protein addition to the database. This entry was referenced in Bryk and co-workers. (2017).