Inter-alpha-trypsin inhibitor heavy chain H1 (ITIH1)
The protein contains 911 amino acids for an estimated molecular weight of 101389 Da.
May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.', 'Contains a potential peptide which could stimulate a broad spectrum of phagocytotic cells. (updated: Oct. 10, 2018)
Protein identification was indicated in the following studies:
Methods
The following articles were analysed to gather the proteome content of erythrocytes.
The gene or protein list provided in the studies were processed using the ID mapping API of Uniprot in September 2018. The number of proteins identified and mapped without ambiguity in these studies is indicated below.
Only Swiss-Prot entries (reviewed) were considered for protein evidence assignation.
| Publication | Identification 1 | Uniprot mapping 2 | Not mapped / Obsolete | TrEMBL | Swiss-Prot |
|---|---|---|---|---|---|
| Goodman (2013) | 2289 (gene list) | 2278 | 53 | 20599 | 2269 |
| Lange (2014) | 1234 | 1234 | 7 | 28 | 1224 |
| Hegedus (2015) | 2638 | 2622 | 0 | 235 | 2387 |
| Wilson (2016) | 1658 | 1528 | 170 | 291 | 1068 |
| d'Alessandro (2017) | 1826 | 1817 | 2 | 0 | 1815 |
| Bryk (2017) | 2090 | 2060 | 10 | 108 | 1942 |
| Chu (2018) | 1853 | 1804 | 55 | 362 | 1387 |
1 as available in the article and/or in supplementary material
2 uniprot mapping returns all protein isoforms as one entry
The compilation of older studies can be retrieved from the Red Blood Cell Collection database.
The data and differentiation stages presented below come from the proteomic study and analysis performed by our partners of the GReX consortium, more details are available in their published work.
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| Variant | Description |
|---|---|
| dbSNP:rs1042777 | |
| allele ITIH1*2 | |
| allele ITIH1*2 and allele ITIH1*3 | |
| dbSNP:rs1042904 | |
| dbSNP:rs1042849 |
No binding partner found
The reference OMIM entry for this protein is 147270
Inter-alpha-trypsin inhibitor, heavy chain 1; itih1
Iatih
Itih
DESCRIPTION
The inter-alpha-trypsin inhibitors (ITI) are a family of structurally related plasma serine protease inhibitors involved in extracellular matrix stabilization and in prevention of tumor metastasis. The ITI family contains multiple proteins made up of a light chain (see 176870) and a variable number of heavy chains (Salier et al., 1987; Himmelfarb et al., 2004).CLONING
Salier et al. (1987) characterized cDNAs for the H chain of IATI. Diarra-Mehrpour et al. (1989) showed that human poly(A)-rich RNAs hybrid-selected with various heavy-chain-encoding cDNA clones translate 3 different heavy chains, designated H1 (M(r) 92,000), H2 (ITIH2; 146640; M(r) 98,000), and H3 (ITIH3; 146650; M(r) 107,000). Two previously characterized heavy-chain cDNA clones were found to correspond to the H1 and H2 chains. The deduced amino acid sequence of the H3 chain was found to be highly similar to those of the H1 (54%) and H2 (44%) chains. Diarra-Mehrpour et al. (1992) used a PCR-based cloning approach and cDNA library screening to isolate the full-length cDNA H1. The results of Northern blot analysis by Bost et al. (1993) indicated that the 2.9-kb ITIH1 mRNA is expressed only in liver.GENE STRUCTURE
Bost et al. (1993) determined that the ITIH1 gene contains 22 exons and spans 14 kb. The authors found evidence for alternative splicing of at least 1 exon of the ITIH1 gene.MAPPING
In situ hybridization by Diarra-Mehrpour et al. (1989) showed that the H1 and H3 genes are located in the 3p21.2-p21.1 region, whereas the H2 gene resides at 10p15. Diarra-Mehrpour et al. (1994) demonstrated that the ITIH1 and ITIH3 genes are arranged in tandem, 2,721 bp apart. Diarra-Mehrpour et al. (1998) reported that the ITIH4 (600564) gene is located just downstream of the last ITIH3 exon, and is transcribed in the opposite orientation.MOLECULAR GENETICS
Genetic polymorphisms of inter-alpha-trypsin inhibitor was first described by Vogt and Cleve (1990) and were subsequently shown to be characteristic of the ITI heavy chain 1 (Vogt et al., 1994); see 147270.0001-147270.0003. Luckenbach et al. (1991) demonstrated mendelian polymorphism of ITI by isoelectric focusing in agarose gels followed by protein blotting and immunoassay. Two common and 1 rare codominant allele were identified with the frequencies: ITI*1 = 0.600, ITI*2 = 0.393, and ITI*3 = 0.007. Vogt et al. (1991) described new alleles in South Koreans and Iranians. ... More on the omim web site
June 30, 2020: Protein entry updated
Automatic update: OMIM entry 147270 was added.
Oct. 19, 2018: Additional information
Initial protein addition to the database. This entry was referenced in Bryk and co-workers. (2017).