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Experimental 3D structures
Below are fixed pre-compiled database outputs

Agouti-related

Alpha-amylase inhibitor

Algae

Bacteria

Bug

Ciliate

Conotoxin1

Conotoxin2

Conotoxin3

Cyclotide

Fungi1

Fungi2

Gurmarin-like

Horseshoe crab

Insect1

Insect2

Maize

Metallocarboxypeptidase inhibitor

Mycetozoa

Plant antimicrobial

Plant defensin

Plant toxin

Plant toxin2

Scorpion1

Scorpion2

Serine protease inhibitor1

Serine protease inhibitor2

Serine protease inhibitor3

Spider

Sponge

Trematoda

Trichoplax

Virus1

Virus2

Water flea

Please note the link significations in the following table
points at individual protein cards (structural data, "Colliers de Perles" ...)
Jmol runs the Jmol viewing applet (loops '(a)', 'b', 'c', '(d)' and 'e' are colored green, salmon, aquamarine, light blue and pink, respectively
R points at renumbered PDB files according to the knottin unique numbering
F points at structurally fitted PDB files (useful for easy 3D comparisons)
  Note: superimposed PDBs and/or 3D models can be viewed (Jmol) using the checkboxes and the form below

Agouti-related

5 three-dimensional structures of Agouti-related knottins


To display Sequence alignments OR Jmol Structural superimpositions of selected knottins:
1 - Use the checkboxes to make selection or use the 'Select All' button
2 - Choose either a 1D Sequence alignment or a 3D Structural superimposition
 
 Nomenclature   Family   SwissProt   PDBsum   Chain   Length   RMS   Descriptor   Experimental   Source   Function   PubMed 

Jmol
(6)6.0(5)10
 Agouti-related   AGRP_HUMAN   1hyk  R F  A   46   0.783   Agouti related protein   Solution nmr   Synthetic   Appetite-stimulating   10371151 

Jmol
(6)6.0(5)10
 Agouti-related   AGRP_HUMAN   1mr0  R F  A   34   1.071   Agouti related protein   Solution nmr   Synthetic   Appetite-stimulating   12056887 

Jmol
(6)6.0(5)10
 Agouti-related   ASIP_HUMAN   1y7j  R F  A   53   1.154   Agouti switch protein, agouti signaling protein   Solution nmr   Synthetic   Involved in the regulation of melanogenesis   15701517 

Jmol
(6)6.0(5)10
 Agouti-related   ASIP_HUMAN   1y7k  R F  A   53   1.207   Agouti switch protein, agouti signaling protein   Solution nmr   Synthetic   Involved in the regulation of melanogenesis   15701517 

Jmol
(6)6.0(5)10
 Agouti-related   ASIP_HUMAN   2kza  R F  A   53   1.154   Asp, agouti switch protein, agouti-signaling protein   Solution nmr   Synthetic homo sapiens   Involved in the regulation of melanogenesis. May affect the   20831872 

To display Sequence alignments OR Jmol Structural superimpositions of selected knottins:
1 - Use the checkboxes to make selection or use the 'Select All' button
2 - Choose either a 1D Sequence alignment or a 3D Structural superimposition

Alpha-amylase inhibitor

7 three-dimensional structures of Alpha-amylase inhibitor knottins


To display Sequence alignments OR Jmol Structural superimpositions of selected knottins:
1 - Use the checkboxes to make selection or use the 'Select All' button
2 - Choose either a 1D Sequence alignment or a 3D Structural superimposition
 
 Nomenclature   Family   SwissProt   PDBsum   Chain   Length   RMS   Descriptor   Experimental   Source   Function   PubMed 

Jmol
(6)8.0(4)7
 Alpha-amylase inhibitor   IAAI_AMAHP   1clv  R F  I   32   0.386   Alpha-amylas   X-ray diffraction   Synthetic   Insect alpha-amylase inhibitor   10508777 

Jmol
(6)8.0(4)7
 Alpha-amylase inhibitor   IAAI_AMAHP   1htx  R F  A   32   0.826   Alpha-amylase inhibitor aai   Solution nmr   Amaranthus hypochondriacus   Insect alpha-amylase inhibitor   11298757 

Jmol
(6)8.0(4)7
 Alpha-amylase inhibitor   IAAI_AMAHP   1qfd  R F  A   32   0.903   Alpha-amylas   Solution nmr   Amaranthus hypochondriacus   Insect alpha-amylase inhibitor   10400675 

Jmol
(6)6.0(4)7
 Alpha-amylase inhibitor   U5JE23_ALLCA   2mi9  R F  A   30   0.939   Allotide C4, conformation 1   Solution nmr   Allamanda cathartica   Sequence homology places Ec-AMP1 in the plant C6-type of antimicrobial peptides, but the three dimensional structure is highly similar to that of a spider neurotoxin   25832441 

Jmol
(6)6.0(4)7
 Alpha-amylase inhibitor   U5JE23_ALLCA   2mia  R F  A   30   0.965   Allotide C4, conformation 2   Solution nmr   Allamanda cathartica   Sequence homology places Ec-AMP1 in the plant C6-type of antimicrobial peptides, but the three dimensional structure is highly similar to that of a spider neurotoxin   25832441 

Jmol
(6)5.0(4)8
 Alpha-amylase inhibitor   V5W9K8_9GENT   4bfh  R F  A   30   0.351   Alpha amylase inhibitor Wrightide R1   X-ray   Wrightia religiosa   May bind to insect α-amylase via a different set of interactions   25040200 

Jmol
(6)5.0(4)8
 Alpha-amylase inhibitor   V5W9K8_9GENT   2mau  R F  A   30   0.752   Alpha-amylase inhibitor wrightide R1 (wR1)   Solution nmr   Wrightia religiosa   May bind to insect α-amylase via a different set of interactions   25040200 

To display Sequence alignments OR Jmol Structural superimpositions of selected knottins:
1 - Use the checkboxes to make selection or use the 'Select All' button
2 - Choose either a 1D Sequence alignment or a 3D Structural superimposition

Algae

0 three-dimensional structure of Algae knottins

 
 


Bacteria

0 three-dimensional structure of Bacteria knottins

 
 


Bug

2 three-dimensional structures of Bug knottins


To display Sequence alignments OR Jmol Structural superimpositions of selected knottins:
1 - Use the checkboxes to make selection or use the 'Select All' button
2 - Choose either a 1D Sequence alignment or a 3D Structural superimposition
 
 Nomenclature   Family   SwissProt   PDBsum   Chain   Length   RMS   Descriptor   Experimental   Source   Function   PubMed 

Jmol
(6)6.0(5)6
 Bug   PTU1_PEITU   1i26  R F  A   34   0.826   Ptu-1   Solution nmr   Peirates turpis   Blocks N-type calcium channel   11669615 

Jmol
(6)6.0(4)6
 Bug   ADO1_AGRDO   1lmr  R F  A   35   1.078   Toxin ado1   Solution nmr   Agriosphodrus dohrni   Binds reversibly and blocks N-type voltage-gated calcium cha   14696181 

To display Sequence alignments OR Jmol Structural superimpositions of selected knottins:
1 - Use the checkboxes to make selection or use the 'Select All' button
2 - Choose either a 1D Sequence alignment or a 3D Structural superimposition

Ciliate

0 three-dimensional structure of Ciliate knottins

 
 


Conotoxin1

38 three-dimensional structures of Conotoxin1 knottins


To display Sequence alignments OR Jmol Structural superimpositions of selected knottins:
1 - Use the checkboxes to make selection or use the 'Select All' button
2 - Choose either a 1D Sequence alignment or a 3D Structural superimposition
 
 Nomenclature   Family   SwissProt   PDBsum   Chain   Length   RMS   Descriptor   Experimental   Source   Function   PubMed 

Jmol
(6)3.0(4)7
 Conotoxin1   CGS_CONGE   1ag7  R F  A   34   0.642   Conotoxin gs   Solution nmr   Conus geographus   Inhibits sodium channel   9115446 

Jmol
(6)6.0(3)5
 Conotoxin1   CO17A_CONPU   1av3  R F  A   27   0.701   Kappa-pviia   Solution nmr   Conus purpurascens   Blocks potassium channel   9438859 

Jmol
(6)6.0(3)5
 Conotoxin1   CO7C_CONMA   1cnn  R F  A   27   0.683   Mviic, omega-conotoxin mviic   Solution nmr   Synthetic   Blocks P/Q-type calcium channel   10373375 

Jmol
(6)6.0(3)4
 Conotoxin1   CO17A_CONMA   1dw4  R F  A   26   0.851   Omega-conotoxin mviia   Solution nmr   Synthetic   Blocks N-type calcium channel   10747778 

Jmol
(6)6.0(3)4
 Conotoxin1   CO17A_CONMA   1dw5  R F  A   26   0.986   Omega-conotoxin mviia   Solution nmr   Synthetic   Blocks N-type calcium channel   10747778 

Jmol
(6)3.0(4)4
 Conotoxin1   C7A_CONTU   1eyo  R F  A   30   0.874   Conotoxin tviia   Solution nmr   Synthetic   May inhibit sodium channel   10903497 

Jmol
(6)6.0(3)3
 Conotoxin1   CO7_CONTE   1f3k  R F  A   26   0.851   Omega-conotoxin txvii   Solution nmr   Synthetic   Blocks L-type calcium channel   11101291 

Jmol
(6)6.0(3)4
 Conotoxin1   CO17A_CONMA   1feo  R F  A   26   0.976   Omega-conotoxin mviia-gly   Solution nmr   Synthetic   Blocks N-type calcium channel   11344322 

Jmol
(6)6.0(3)4
 Conotoxin1   CO16A_CONTE   1fu3  R F  A   27   0.455   Txia, conotoxin king-kong 0, kk-0, delta-conotoxin txvia   Solution nmr   Synthetic   Inhibits sodium current inactivation   12145313 

Jmol
(6)6.0(3)4
 Conotoxin1   CO13_CONST   1fyg  R F  A   25   0.889   Omega conotoxin so3   Solution nmr   Synthetic   Inhibits calcium channel   _ 

Jmol
(6)9.0(3)3
 Conotoxin1   CO6A_CONER   1g1p  R F  A   33   0.441   Conotoxin evia   Solution nmr   Synthetic   Inhibits neuronal sodium channel   14976206 

Jmol
(6)9.0(3)3
 Conotoxin1   CO6A_CONER   1g1z  R F  A   33   0.640   Conotoxin evia   Solution nmr   Synthetic   Blocks mu1 sodium channel   14976206 

Jmol
(6)6.0(3)5
 Conotoxin1   CO17A_CONPU   1kcp  R F  A   28   0.683   Kappa-conotoxin pviia   Solution nmr   Conus purpurascens   Inhibits the shaker potassium channel   9548922 

Jmol
(6)6.0(3)4
 Conotoxin1   CO17A_CONMA   1mvi  R F  A   26   0.849   Omega-conotoxin mviia, mviia   Solution nmr   Conus magus   Blocks N-type calcium channel   8913308 

Jmol
(6)6.0(3)5
 Conotoxin1   CO16B_CONST   1mvj  R F  A   27   0.855   Omega-conotoxin svib, svib   Solution nmr   Conus striatus   Blocks N-type calcium channel   8913308 

Jmol
(6)6.0(2)6
 Conotoxin1   CO16A_CONGE   1omc  R F  A   28   0.745   Omega-conotoxin gvia   Solution nmr   Conus geographus   Blocks N-type calcium channel   8338837 

Jmol
(6)6.0(3)4
 Conotoxin1   CO17A_CONMA   1omg  R F  A   26   0.765   Omega-conotoxin mviia   Solution nmr   Conus magus   Blocks N-type calcium channel   7640281 

Jmol
(6)6.0(3)5
 Conotoxin1   CO7C_CONMA   1omn  R F  A   27   0.883   Snx-23, omega-conotoxin m vii c (m seven c)   Solution nmr   Conus magus   Blocks P/Q type calcium channel   7731037 

Jmol
(6)9.0(4)4
 Conotoxin1   CO16B_CONMR   1rmk  R F  A   31   0.754   Mu-o-conotoxin mrvib   Solution nmr   Conus marmoreus   Blocks voltage-sensitive sodium channel and fast-inactivatin   15044438 

Jmol
(6)6.0(2)6
 Conotoxin1   CO16A_CONGE   1tr6  R F  A   28   0.836   Omega-conotoxin gvia   Solution nmr   Conus geographus   Blocks N-type calcium channels   15166237 

Jmol
(6)6.0(3)4
 Conotoxin1   CO17A_CONMA   1tt3  R F  A   26   0.821   Omega-conotoxin [k10]mviia, omega-conotoxin mviia   Solution nmr   Synthetic   Blocks N-type calcium channels   12441339 

Jmol
(6)6.0(3)4
 Conotoxin1   CO17A_CONMA   1ttk  R F  A   26   0.560   Omega-conotoxin mviia   Solution nmr   Synthetic   Blocks N-type calcium channels   12441339 

Jmol
(6)6.0(2)6
 Conotoxin1   CO16A_CONGE   1ttl  R F  A   28   0.981   Omega-conotoxin gvia   Solution nmr   Conus geographus   Blocks N-type calcium channels   15166237 

Jmol
(6)6.0(3)5
 Conotoxin1   CO7C_CONMA   1v4q  R F  A   27   0.543   Omega-conotoxin mviic   Solution nmr   Synthetic   Blocks N-type calcium channels and some types of high-thresh   _ 

Jmol
(6)6.0(3)3
 Conotoxin1   CO66_CONAA   1yz2  R F  A   27   1.492   Delta-conotoxin am 2766   Solution nmr   Conus amadis   Inhibits the inactivation of voltage-sensitive sodium channe   _ 

Jmol
(6)6.0(2)6
 Conotoxin1   CO16A_CONGE   2cco  R F  A   28   0.822   Omega-conotoxin gvia   Solution nmr   Conus geographus   Blocks N-type calcium channel   10231724 

Jmol
(6)5.0(2)4
 Conotoxin1   CI1BA_CONRA   2jry  R F  A   46   0.983   R11., i-superfamily conotoxin r11a   Solution nmr   Conus radiatus   Binds sodium channels and affects their activation   17696362 

Jmol
(6)5.0(2)4
 Conotoxin1   CI1BA_CONRA   2jtu  R F  A   38   1.187   R11.6, i-superfamily conotoxin r11a   Solution nmr   Synthetic   Binds sodium channels (Nav1.6/SCN8A)   _ 

Jmol
(6)6.0(3)4
 Conotoxin1   _   2km9  R F  A   25   0.910   Omega_conotoxin-fvia   Solution nmr   Synthetic   Blocks N-type calcium channel   PMED 

Jmol
(6)5.0(2)4
 Conotoxin1   CI1BA_CONRA   2p4l  R F  A   46   1.153   R11.6, conotoxin iota-rxia, i-superfamily conotoxin r11a   Solution nmr   Conus radiatus   Binds sodium channels and affects their activation   17696362 

Jmol
(0)6.3(5)0
 Conotoxin1   CM3B_CONBU   2lo9  R F  A   25   2.614   Mu-contoxin BuIIIB   Solution nmr   Conus bullatus   Mammalian neuronal sodium channel blocker   23557677 

Jmol
(0)6.3(5)0
 Conotoxin1   CM3B_CONBU   2loc  R F  A   25   2.531   [d-Ala2]BuIIIB contoxin   Solution nmr   Conus bullatus   Mammalian neuronal sodium channel blocker   23557677 

Jmol
(0)1.4(5)0
 Conotoxin1   CM3A_CONKI   2lxg  R F  A   17   -   Mu-conotoxin KIIIA   Solution nmr   Conus kinoshitai   Potent blocker of Na(V)1.2   23167564 

Jmol
(6)9.0(4)4
 Conotoxin1   A0A0K2SEF6_CONEP   2n7f  R F  A   32   0.910   MuO-conotoxin MfVIA   Solution nmr   Synthetic construct   Inhibits the voltage-gated sodium channel NaV1.8   27026701 

Jmol
(6)6.0(3)6
 Conotoxin1   CO17J_CONGE   2n8h  R F  A   35   0.790   Mu-conotoxin GVIIJ   Solution nmr   Conus geographus   Blocks voltage-gated sodium channels (Nav)   26817840 

Jmol
(0)5.4(5)0
 Conotoxin1   GM3C_CONCN   2yen  R F  A   23   2.365   Mu-conotoxin CnIIIC   Solution nmr   Conus consors   Blocks voltage-gated sodium channels (Nav)   22229737 

Jmol
(0)7.2(1)3
 Conotoxin1   CEX_CONCN   4b1q  R F  P   30   -   Conotoxin CcTx (O-Glycosylated Conopeptide Cctx)   Solution nmr   Conus consors   May specifically activate neuronal voltage-gated sodium channels (Nav) at the resting membrane potential.   23281027 

Jmol
(6)6.0(3)5
 Conotoxin1   CO17A_CONPU   2n8e  R F  A   34   1.194   Kappa-conotoxin PVIIA   Solution nmr   Conus purpurascens   This toxin inhibits the Shaker channel from insects.   27093300 

To display Sequence alignments OR Jmol Structural superimpositions of selected knottins:
1 - Use the checkboxes to make selection or use the 'Select All' button
2 - Choose either a 1D Sequence alignment or a 3D Structural superimposition

Conotoxin2

3 three-dimensional structure of Conotoxin2 knottins


To display Sequence alignments OR Jmol Structural superimpositions of selected knottins:
1 - Use the checkboxes to make selection or use the 'Select All' button
2 - Choose either a 1D Sequence alignment or a 3D Structural superimposition
 
 Nomenclature   Family   SwissProt   PDBsum   Chain   Length   RMS   Descriptor   Experimental   Source   Function   PubMed 

Jmol
(3)5.3(1)4
 Conotoxin2   CP91_CONGL   1ixt  R F  A   27   0.929   Spasmodic protein tx9a-like protein   Solution nmr   Synthetic   Unknown   12193600 

Jmol
(3)5.3(1)4
 Conotoxin2   CP91_CONGL   2mso  R F  A   30   -   Conotoxin Gm9.1   Solution nmr   Conus gloriamaris   "Elicits ""spasmodic"" symptomatology."   26172377 

Jmol
(3)3.3(1)4
 Conotoxin2   CP91_CONGL   2msq  R F  A   27   0.914   Conotoxin cBru9a   Solution nmr   Synthetic construct   -   26172377 

To display Sequence alignments OR Jmol Structural superimpositions of selected knottins:
1 - Use the checkboxes to make selection or use the 'Select All' button
2 - Choose either a 1D Sequence alignment or a 3D Structural superimposition

Conotoxin3

0 three-dimensional structure of Conotoxin3 knottins

 
 


Cyclotide

35 three-dimensional structures of Cyclotide knottins


To display Sequence alignments OR Jmol Structural superimpositions of selected knottins:
1 - Use the checkboxes to make selection or use the 'Select All' button
2 - Choose either a 1D Sequence alignment or a 3D Structural superimposition
 
 Nomenclature   Family   SwissProt   PDBsum   Chain   Length   RMS   Descriptor   Experimental   Source   Function   PubMed 

Jmol
(3)4.6(1)4[6]
 Cyclotide   CIRA_CHAPA   1bh4  R F  A   30   1.016   Circulin a   Solution nmr   Chassalia parviflora   anti-HIV   9878410 

Jmol
(4)7.1(4)5[5]
 Cyclotide   CYO1_VIOOD   1df6  R F  A   30   1.343   Cycloviolacin o1   Solution nmr   Viola odorata   Cytotoxic   10600388 

Jmol
(0)0.0(0)0[7]
 Cyclotide   KAB1_OLDAF   1jjz  R F  A   29   1.407   Kalata b1   Solution nmr   Oldenlandia affinis   Uterotonic   11888199 

Jmol
(0)0.0(0)0[7]
 Cyclotide   KAB1_OLDAF   1k48  R F  A   29   1.487   Kalata b1   Solution nmr   Oldenlandia affinis   Uterotonic   11888199 

Jmol
(7)3.4(4)1[7]
 Cyclotide   KAB1_OLDAF   1kal  R F  A   29   1.206   Kalata b1   Solution nmr   Oldenlandia affinis   Uterotonic   7703226 

Jmol
(3)4.4(1)4[7]
 Cyclotide   KAB1_OLDAF   1nb1  R F  A   29   0.956   Kalata b1   Solution nmr   Oldenlandia affinis   Uterotonic   12482868 

Jmol
(3)4.7(1)4[5]
 Cyclotide   CYO1_VIOOD   1nbj  R F  A   30   1.081   Cycloviolacin o1   Solution nmr   Viola odorata   Cytotoxic   12482868 

Jmol
(3)4.4(1)4
 Cyclotide   KAB1_OLDAF   1orx  R F  A   24   1.087   Kalata b1   Solution nmr   Synthetic   Loss of hemolytic activity compared to native peptide   12779323 

Jmol
(3)4.4(1)4[7]
 Cyclotide   KAB2_OLDAF   1pt4  R F  A   29   1.184   Kalata b2   Solution nmr   Oldenlandia affinis   Probably participates in a plant defense mechanism   15654741 

Jmol
(3)5.7(1)7[8]
 Cyclotide   PALIC_PALCO   1r1f  R F  A   37   1.392   Palicourein   Solution nmr   Palicourea condensata   Anti-HIV   14725768 

Jmol
(3)4.7(1)4[5]
 Cyclotide   VHR1_VIOHE   1vb8  R F  A   30   1.202   Vhr, viola hederacea root peptide 1   Solution nmr   Viola hederacea   Probably participates in a plant defense mechanism   15295104 

Jmol
(3)4.4(1)5[10]
 Cyclotide   TRIC_VIOAR   1yp8  R F  A   33   1.211   Tricyclon a   Solution nmr   Viola tricolor   -   15893660 

Jmol
(3)5.6(1)4[6]
 Cyclotide   VHL1_VIOHE   1za8  R F  A   31   0.917   Vhl-1   Solution nmr   Viola hederacea   Probably involved in plant defense. Has antiviral activity   15824119 

Jmol
(3)4.4(1)4[7]
 Cyclotide   KAB4_OLDAF   1znu  R F  A   29   1.091   Kalata b1   Solution nmr   Oldenlandia affinis   Uterotonic. Probably involved in plant defense   16817894 

Jmol
(3)4.4(1)5[8]
 Cyclotide   KAB8_OLDAF   2b38  R F  A   31   1.160   Kalata b8   Solution nmr   Oldenlandia affinis   Probably involved in plant defense. Has antiviral activity   16207177 

Jmol
(3)4.6(1)4[7]
 Cyclotide   CIRB_CHAPA   2eri  R F  A   31   0.826   Cirb, circulin b   Solution nmr   Chassalia parviflora   Probably involved in plant defense. Antiviral and antibiotic   _ 

Jmol
(3)4.4(1)4[7]
 Cyclotide   KAB1_OLDAF   2f2i  R F  A   29   1.030   Kalata-b1   Solution nmr   Synthetic   _   16300479 

Jmol
(3)4.4(1)4[7]
 Cyclotide   KAB1_OLDAF   2f2j  R F  A   29   1.105   Kalata-b1   Solution nmr   Synthetic   _   16300479 

Jmol
(3)4.4(1)4
 Cyclotide   VIOLA_VIOOD   2fqa  R F  A   27   1.768   Violacin , violacin 1   Solution nmr   Viola odorata   Reduced hemolytic activity vs cyclotides   16488428 

Jmol
(3)4.4(1)5[8]
 Cyclotide   CYO14_VIOOD   2gj0  R F  A   31   1.159   Cycloviolacin o14   Solution nmr   Viola odorata   _   16872274 

Jmol
(3)4.4(1)4[7]
 Cyclotide   KAB7_OLDAF   2jwm  R F  A   29   1.157   Kalata-b7   Solution nmr   Oldenlandia affinis   Probably involved in plant defense. Hemolytic.   18295894 

Jmol
(3)4.4(1)4[7]
 Cyclotide   VARF_VIOAR   2k7g  R F  A   29   0.911   Varv peptide f   Solution nmr   Viola arvensis   Probably participates in a plant defense mechanism, Cytotoxi   19211551 

Jmol
(3)4.6(1)4[6]
 Cyclotide   CYO2_VIOOD   2kcg  R F  A   30   1.243   Cycloviolacin-o2   Solution nmr   Viola odorata   Probably participates in a plant defense mechanism. Cytotoxi   - 

Jmol
(3)4.4(1)4[7]
 Cyclotide   KAB2_OLDAF   2kch  R F  A   29   1.123   Kalata-b2   Solution nmr   Oldenlandia affinis   Probably participates in a plant defense mechanism. Insectic   - 

Jmol
(3)4.4(1)4
 Cyclotide   KAB1_OLDAF   2khb  R F  A   29   0.971   Linear kalata-b1   Solution nmr   Oldenlandia affinis   _   _ 

Jmol
(3)4.6(1)4
 Cyclotide   CYO2_VIOOD   2knm  R F  A   30   0.692   Cycloviolacin-o2   Solution nmr   Viola odorata   Cytotoxic, hemolytic   19735083 

Jmol
(3)4.4(1)5
 Cyclotide   VHL2_VIOHE   2kuk  R F  A   30   1.243   Vhl-2, leaf cyclotide 2   Solution nmr   Viola hederacea   Probably participates in a plant defense mechanism. Has hemo   _ 

Jmol
(3)4.6(1)4
 Cyclotide   KAB5_OLDAF   2kux  R F  A   30   1.232   Kalata-b5   Solution nmr   Oldenlandia affinis   Probably involved in plant defense   20564013 

Jmol
(3)4.4(1)4
 Cyclotide   KAB12_OLDAF   2kvx  R F  A   28   0.924   Kalata-b12   Solution nmr   Synthetic oldenlandia affinis   Probably participates in a plant defense mechanism   _ 

Jmol
(3)4.4(1)4
 Cyclotide   _   2lam  R F  A   29   0.958   Cyclotide cter m   Solution nmr   Synthetic clitoria ternatea   Probably participates in a plant defense mechanism. Has inse   21593408 

Jmol
(3)4.4(1)4[7]
 Cyclotide   VARF_VIOAR   3e4h  R F  A   29   0.906   Varv peptide f   X-ray diffraction   Viola arvensis   Probably participates in a plant defense mechanism. Cytotoxi   19211551 

Jmol
(3)4.4(1)4
 Cyclotides   KAB4_OLDAF   2lur  R F  A   29   1.785   KB1(GHFRWG;23-28), synthesized melanocortin analogue of kalata B1   Solution nmr   Synthetic   Selective MC4R (melanocortin receptor 4) agonist   23012369 

Jmol
(3)4.4(1)4
 Cyclotides   KAB7_OLDAF   2m9o  R F  A   29   0.845   Oxytocic plant peptide kalata B7   Solution nmr   Oldenlandia affinis   Probably participates in a plant defense mechanism. Has hemolytic activity.   24248349 

Jmol
(3)4.4(1)4
 Cyclotides   KAB1_OLDAF   2mh1  R F  A   33   1.033   Kalata-B1, Fragment: UNP Residues 93-120   Solution nmr   Oldenlandia affinis   Probably participates in a plant defense mechanism. Has antibiotic activity. Has a diuretic effect. Has a uterotonic effect in humans.   24425873 

Jmol
(3)4.4(1)5
 Cyclotides   KAB1_OLDAF   2mn1  R F  A   30   0.973   kalata B1[W23WW]    Solution nmr   Oldenlandia affinis   Probably participates in a plant defense mechanism. Has antibiotic activity. Has a diuretic effect. Has a uterotonic effect in humans.   25099014 

To display Sequence alignments OR Jmol Structural superimpositions of selected knottins:
1 - Use the checkboxes to make selection or use the 'Select All' button
2 - Choose either a 1D Sequence alignment or a 3D Structural superimposition

Fungi1

0 three-dimensional structure of Fungi1 knottins

 
 


Fungi2

0 three-dimensional structure of Fungi2 knottins

 
 


Gurmarin-like

2 three-dimensional structures of Gurmarin-like knottins


To display Sequence alignments OR Jmol Structural superimpositions of selected knottins:
1 - Use the checkboxes to make selection or use the 'Select All' button
2 - Choose either a 1D Sequence alignment or a 3D Structural superimposition
 
 Nomenclature   Family   SwissProt   PDBsum   Chain   Length   RMS   Descriptor   Experimental   Source   Function   PubMed 

Jmol
(6)6.0(4)9
 Gurmarin-like   GUR_GYMSY   1c4e  R F  A   35   1.198   Gurmarin   Solution nmr   Gymnema sylvestre   Sweet taste suppressing   10491100 

Jmol
(0)0.0(0)0
 Gurmarin-like   GUR_GYMSY   1gur  R F  A   35   1.119   Gurmarin   Solution nmr   Gymnema sylvestre   Sweet taste suppressing   7787425 

To display Sequence alignments OR Jmol Structural superimpositions of selected knottins:
1 - Use the checkboxes to make selection or use the 'Select All' button
2 - Choose either a 1D Sequence alignment or a 3D Structural superimposition

Horseshoe crab

3 three-dimensional structures of Horseshoe crab knottins


To display Sequence alignments OR Jmol Structural superimpositions of selected knottins:
1 - Use the checkboxes to make selection or use the 'Select All' button
2 - Choose either a 1D Sequence alignment or a 3D Structural superimposition
 
 Nomenclature   Family   SwissProt   PDBsum   Chain   Length   RMS   Descriptor   Experimental   Source   Function   PubMed 

Jmol
(6)11.0(4)11
 Horseshoe crab   TACA2_TACTR   1cix  R F  A   44   1.011   Tachystati   Solution nmr   Tachypleus tridentatus   Antimicrobial   11959852 

Jmol
(6)7.0(4)11
 Horseshoe crab   TACB1_TACTR   2dcv  R F  A   42   0.767   Tachystatin-b1   Solution nmr   Tachypleus tridentatus   Antimicrobial, binds to chitin   17394123 

Jmol
(6)7.0(4)11
 Horseshoe crab   TACB2_TACTR   2dcw  R F  A   42   0.730   Tachystatin-b2   Solution nmr   Tachypleus tridentatus   Antimicrobial, binds to chitin   17394123 

To display Sequence alignments OR Jmol Structural superimpositions of selected knottins:
1 - Use the checkboxes to make selection or use the 'Select All' button
2 - Choose either a 1D Sequence alignment or a 3D Structural superimposition

Insect1

1 three-dimensional structure of Insect1 knottins


To display Sequence alignments OR Jmol Structural superimpositions of selected knottins:
1 - Use the checkboxes to make selection or use the 'Select All' button
2 - Choose either a 1D Sequence alignment or a 3D Structural superimposition
 
 Nomenclature   Family   SwissProt   PDBsum   Chain   Length   RMS   Descriptor   Experimental   Source   Function   PubMed 

Jmol
(6)8.0(3)10
 Insect1   ALO3_ACRLO   1q3j  R F  A   36   0.881   Alo3   Solution nmr   Synthetic   Antifungal protein   14661954 

To display Sequence alignments OR Jmol Structural superimpositions of selected knottins:
1 - Use the checkboxes to make selection or use the 'Select All' button
2 - Choose either a 1D Sequence alignment or a 3D Structural superimposition

Insect2

0 three-dimensional structure of Insect2 knottins

 
 


Maize

0 three-dimensional structure of Maize knottins

 
 


Metallocarboxypeptidase inhibitor

3 three-dimensional structures of Metallocarboxypeptidase inhibitor knottins


To display Sequence alignments OR Jmol Structural superimpositions of selected knottins:
1 - Use the checkboxes to make selection or use the 'Select All' button
2 - Choose either a 1D Sequence alignment or a 3D Structural superimposition
 
 Nomenclature   Family   SwissProt   PDBsum   Chain   Length   RMS   Descriptor   Experimental   Source   Function   PubMed 

Jmol
(3)5.5(2)6
 Metallocarboxypeptidase inhibitor   MCPI_SOLTU   1h20  R F  A   39   0.967   Carboxypeptidase inhibitor, mcpi, metallocarboxypeptidase inhibitor   Solution nmr   Solanum tuberosum   Carboxypeptidase A inhibitor   12557184 

Jmol
(3)5.5(2)13
 Metallocarboxypeptidase inhibitor   FSPM_SOLLC   2hlg  R F  A   39   0.939   Fruit-specific protein   Solution nmr   Lycopersicon esculentum   _   _ 

Jmol
(3)5.5(2)6
 Metallocarboxypeptidase inhibitor   MCPI_SOLTU   4cpa  R F  I   38   0.924   Metallocarboxypeptidase inhibitor   X-ray diffraction   Solanum tuberosum   Carboxypeptidase A inhibitor   7154070 

To display Sequence alignments OR Jmol Structural superimpositions of selected knottins:
1 - Use the checkboxes to make selection or use the 'Select All' button
2 - Choose either a 1D Sequence alignment or a 3D Structural superimposition

Mycetozoa

0 three-dimensional structure of Mycetozoa knottins

 
 


Plant antimicrobial

2 three-dimensional structure of Plant antimicrobial knottins


To display Sequence alignments OR Jmol Structural superimpositions of selected knottins:
1 - Use the checkboxes to make selection or use the 'Select All' button
2 - Choose either a 1D Sequence alignment or a 3D Structural superimposition
 
 Nomenclature   Family   SwissProt   PDBsum   Chain   Length   RMS   Descriptor   Experimental   Source   Function   PubMed 

Jmol
(6)8.0(3)10
 Plant antimicrobial   PAFP_PHYAM   1dkc  R F  A   38   0.683   Pafp-, antifungal peptide   Solution nmr   Phytolacca americana   Antifungal   11551192 

Jmol
(6)6.0(4)4
 Plant antimicrobial   A0A1S4NYD9_9ROSI   5gsf  R F  A   27   1.252   Roseltide rT1   Solution nmr   Hibiscus sabdariffa   Roseltide rT1 was shown to inhibit human neutrophil elastase using enzymatic and pull-down assays.   27991569 

To display Sequence alignments OR Jmol Structural superimpositions of selected knottins:
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Plant defensin

1 three-dimensional structure of Plant defensin knottins


To display Sequence alignments OR Jmol Structural superimpositions of selected knottins:
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 Nomenclature   Family   SwissProt   PDBsum   Chain   Length   RMS   Descriptor   Experimental   Source   Function   PubMed 

Jmol
(6)5.2(10)6
 Plant defensin   DEF1_PETHY   1n4n  R F  A   47   0.910   Phd, floral defensin-like protein 1   Solution nmr   Petunia x hybrida   Floral defensin-like protein 1   12846570 

To display Sequence alignments OR Jmol Structural superimpositions of selected knottins:
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Plant toxin

2 three-dimensional structures of Plant toxin knottins


To display Sequence alignments OR Jmol Structural superimpositions of selected knottins:
1 - Use the checkboxes to make selection or use the 'Select All' button
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 Nomenclature   Family   SwissProt   PDBsum   Chain   Length   RMS   Descriptor   Experimental   Source   Function   PubMed 

Jmol
(3)7.4(1)9
 Plant toxin   ALB1_SOYBN   1ju8  R F  A   37   0.976   Albumin 1, leginsulin   Solution nmr   Synthetic   Stimulates phosphorylation of the plant insulin-binding prot   12631285 

Jmol
(3)7.4(1)9
 Plant toxin   ALB1F_PEA   1p8b  R F  A   37   1.231   Pa1b, albumin a1b, leginsuli, pea albumin 1, subunit b   Solution nmr   Pisum sativum   binds to basic 7S globulin (BG) and stimulates its phosphory   14556622 

To display Sequence alignments OR Jmol Structural superimpositions of selected knottins:
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Plant toxin2

1 three-dimensional structures of Plant toxin knottins


To display Sequence alignments OR Jmol Structural superimpositions of selected knottins:
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 Nomenclature   Family   SwissProt   PDBsum   Chain   Length   RMS   Descriptor   Experimental   Source   Function   PubMed 

Jmol
(4)5.3(1)10
 Plant toxin2   D0VWX1_MOMCO   2knp  R F  A   33   1.474   Mcocc-1   Solution nmr   Momordica cochinchinensis   Cytotoxic   19711988 

To display Sequence alignments OR Jmol Structural superimpositions of selected knottins:
1 - Use the checkboxes to make selection or use the 'Select All' button
2 - Choose either a 1D Sequence alignment or a 3D Structural superimposition

Scorpion1

2 three-dimensional structures of Scorpion1 knottins


To display Sequence alignments OR Jmol Structural superimpositions of selected knottins:
1 - Use the checkboxes to make selection or use the 'Select All' button
2 - Choose either a 1D Sequence alignment or a 3D Structural superimposition
 
 Nomenclature   Family   SwissProt   PDBsum   Chain   Length   RMS   Descriptor   Experimental   Source   Function   PubMed 

Jmol
(6)5.0(3)10
 Scorpion1   SCXC_SCOMA   1c6w  R F  A   33   0.887   Mca, maurocalcin   Solution nmr   Synthetic   Acts on a ryanodine-sensitive calcium channel   10861934 

Jmol
(6)5.0(3)10
 Scorpion1   IPTXA_PANIM   1ie6  R F  A   33   0.609   Peptide neurotoxin, ryanodine receptor activator, imperatoxin a   Solution nmr   Synthetic   Ryanodine receptor activator   14535845 

To display Sequence alignments OR Jmol Structural superimpositions of selected knottins:
1 - Use the checkboxes to make selection or use the 'Select All' button
2 - Choose either a 1D Sequence alignment or a 3D Structural superimposition

Scorpion2

4 three-dimensional structures of Scorpion2 knottins


To display Sequence alignments OR Jmol Structural superimpositions of selected knottins:
1 - Use the checkboxes to make selection or use the 'Select All' button
2 - Choose either a 1D Sequence alignment or a 3D Structural superimposition
 
 Nomenclature   Family   SwissProt   PDBsum   Chain   Length   RMS   Descriptor   Experimental   Source   Function   PubMed 

Jmol
(2)10.2(8)4
 Scorpion2   SCXL_LEIQU   1chl  R F  A   36   1.127   Chlorotoxin   Solution nmr   Leiurus quinquestriatus   Blocks chloride channels   7819188 

Jmol
(5)8.2(10)4
 Scorpion2   KGX11_CENNO   1ne5  R F  A   42   0.902   Cnerg1, ergtx, ergtoxin   Solution nmr   Synthetic   Blocks the ether-a-go-go-related K+ channel   12650941 

Jmol
(5)8.2(10)4
 Scorpion2   KGX11_CENNO   1px9  R F  A   42   1.323   Ergtoxin   Solution nmr   Centruroides noxius   Blocks the ether-a-go-go-related K+ channel   15211519 

Jmol
(2)10.2(6)4
 Scorpion2   SCX5_BUTEU   1sis  R F  A   36   1.084   Scorpion insectotoxin i5a   Solution nmr   Mesobuthus eupeus   Short scorpion toxin   1815511 

To display Sequence alignments OR Jmol Structural superimpositions of selected knottins:
1 - Use the checkboxes to make selection or use the 'Select All' button
2 - Choose either a 1D Sequence alignment or a 3D Structural superimposition

Serine protease inhibitor1

24 three-dimensional structures of Serine protease inhibitor1 knottins


To display Sequence alignments OR Jmol Structural superimpositions of selected knottins:
1 - Use the checkboxes to make selection or use the 'Select All' button
2 - Choose either a 1D Sequence alignment or a 3D Structural superimposition
 
 Nomenclature   Family   SwissProt   PDBsum   Chain   Length   RMS   Descriptor   Experimental   Source   Function   PubMed 

Jmol
(6)5.3(1)5
 Serine protease inhibitor1   ITR1_CUCMA   1cti  R F  A   29   0.590   Trypsin inhibitor   Solution nmr   Cucurbita maxima   Trypsin inhibitor   2614837 

Jmol
(6)5.3(1)4
 Serine protease inhibitor1   ITR2_MOMCH   1f2s  R F  I   28   0.257   Trypsin inhibitor a   X-ray diffraction   Momordica charantia   Trypsin inhibitor   10524768 

Jmol
(6)5.3(1)5
 Serine protease inhibitor1   ITR2_ECBEL   1h9h  R F  I   36   0.241   Eeti-ii, trypsin inhibitor ii   X-ray diffraction   Synthetic ecballium elaterium   Trypsin inhibitor   16131759 

Jmol
(6)5.3(1)5
 Serine protease inhibitor1   ITR2_ECBEL   1h9i  R F  I   36   0.278   Eeti-ii, trypsin inhibitor ii   X-ray diffraction   Synthetic ecballium elaterium   Trypsin inhibitor   16131759 

Jmol
(6)5.3(1)5[8]
 Serine protease inhibitor1   ITR2_MOMCO   1ha9  R F  A   34   0.342   Mcoti-ii, trypsin inhibitor ii   Solution nmr   Momordica cochinchinensis   Trypsin inhibitor   11434766 

Jmol
(6)5.3(1)5[8]
 Serine protease inhibitor1   ITR2_MOMCO   1ib9  R F  A   34   0.548   Mcoti-i, trypsin inhibitor ii   Solution nmr   Momordica cochinchinensis   Trypsin inhibitor   11292835 

Jmol
(6)5.3(1)5
 Serine protease inhibitor1   ITR1_CUCMA   1lu0  R F  A   29   0.117   Cmti-i, trypsin inhibitor i   X-ray diffraction   Cucurbita maxima   Trypsin inhibitor   12198301 

Jmol
(6)5.3(1)4
 Serine protease inhibitor1   ITRA_MOMCH   1mct  R F  I   28   0.285   Trypsin inhibitor a   X-ray diffraction   Momordica charantia   Trypsin inhibitor   8445634 

Jmol
(6)5.3(1)5
 Serine protease inhibitor1   ELA1_PIG   1mcv  R F  I   28   0.139   Hybrid squash inhibitor hei-toe 1, hei-toe i   X-ray diffraction   Synthetic   Elastase inhibitor   12554935 

Jmol
(6)5.3(1)5
 Serine protease inhibitor1   ITR1_CUCMA   1ppe  R F  I   29   0.139   Trypsin inhibitor cmti-i   X-ray diffraction      Trypsin inhibitor   2914611 

Jmol
(6)5.3(1)5
 Serine protease inhibitor1   ITR2_ECBEL   1w7z  R F  A   31   0.219   Eeti-ii, trypsin inhibitor ii   X-ray diffraction   Ecballium elaterium   Trypsin inhibitor   16131759 

Jmol
(6)5.3(1)5
 Serine protease inhibitor1   ITR3_CUCPE   2btc  R F  I   29   0.000   Cpti-i, trypsi   X-ray diffraction   Cucurbita pepo   Trypsin inhibitor   10089404 

Jmol
(6)5.3(1)5
 Serine protease inhibitor1   ITR2_MOMCO   2c4b  R F  A   143   0.190   Barnase mcoeeti fusion   X-ray diffraction   Bacillus amyloliquefaciens, momordic   Trypsin inhibitor   16337652 

Jmol
(6)5.3(1)5
 Serine protease inhibitor1   ITR1_CUCMA   2cti  R F  A   29   0.285   Trypsin inhibitor   Solution nmr   Cucurbita maxima   Trypsin inhibitor   2614837 

Jmol
(6)5.3(1)5
 Serine protease inhibitor1   ITR2_ECBEL   2eti  R F  A   28   0.688   Trypsin inhibitor ii   Solution nmr   Ecballium elaterium   Trypsin inhibitor   2622910 

Jmol
(6)5.3(1)5
 Serine protease inhibitor1   ITR2_ECBEL   2it7  R F  A   28   0.246   Trypsin inhibitor ii, eeti-ii, trypsin inhibitor 2   Solution nmr   Synthetic   Trypsin inhibitor   _ 

Jmol
(6)5.3(1)5
 Serine protease inhibitor1   ITR2_MOMCO   2it8  R F  A   30   0.185   Trypsin inhibitor ii, mcoti-ii, trypsin inhibitor 2   Solution nmr   Synthetic   Trypsin inhibitor   _ 

Jmol
(6)5.3(1)5
 Serine protease inhibitor1   ITR2_ECBEL   2let  R F  A   28   0.732   Trypsin inhibitor ii   Solution nmr   Ecballium elaterium   Trypsin inhibitor with reduced affinity   8003965 

Jmol
(6)5.3(1)5
 Serine protease inhibitor1   ITR1_CUCMA   2sta  R F  I   29   0.188   Trypsi   X-ray diffraction   Cucurbita maxima   Trypsin inhibitor   10089404 

Jmol
(6)5.3(1)5
 Serine protease inhibitor1   ITR3_CUCPE   2stb  R F  I   29   0.190   Cpti-i, trypsi   X-ray diffraction   Cucurbita pepo   Trypsin inhibitor   10089404 

Jmol
(6)5.3(1)5
 Serine protease inhibitor1   ITR1_CUCMA   2v1v  R F  A   29   1.021   Trypsin inhibitor i, cmti-i, itd-i, trypsin inhibitor 1   Solution nmr   Synthetic cucurbita maxima   Trypsin inhibitor   10716179 

Jmol
(6)5.3(1)5
 Serine protease inhibitor1   ITR1_CUCMA   3cti  R F  A   29   0.326   Trypsin inhibitor   Solution nmr   Cucurbita maxima   Trypsin inhibitor   2051485 

Jmol
(11)5.3(1)5
 Serine protease inhibitor1   ITR2_ECBEL   2m7t  R F  A   33   0.409   Engineered Cystine Knot Protein 2.5D   Solution nmr   Synthetic construct   Target T0711 in CASP10   24318984 

Jmol
(8)5.3(1)5
 Serine protease inhibitor1   ITR2_MOMCO   2mt8  R F  A   39   0.428   MTAbl13 of grafted MCoTI-II    Solution nmr   Momordica cochinchinensis (Spiny bitter cucumber) (Muricia cochinchinensis)   Inhibits trypsin; probably participates in a plant defense mechanism.   26264857 

To display Sequence alignments OR Jmol Structural superimpositions of selected knottins:
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2 - Choose either a 1D Sequence alignment or a 3D Structural superimposition

Serine protease inhibitor2

0 three-dimensional structure of Serine protease inhibitor2 knottins

 
 


Serine protease inhibitor3

0 three-dimensional structure of Serine protease inhibitor3 knottins

 
 


Spider

73 three-dimensional structures of Spider knottins


To display Sequence alignments OR Jmol Structural superimpositions of selected knottins:
1 - Use the checkboxes to make selection or use the 'Select All' button
2 - Choose either a 1D Sequence alignment or a 3D Structural superimposition
 
 Nomenclature   Family   SwissProt   PDBsum   Chain   Length   RMS   Descriptor   Experimental   Source   Function   PubMed 

Jmol
(7)6.0(4)10
 Spider   TOG4B_AGEAP   1agg  R F  A   48   0.951   Omega-aga-iv, omega-agatoxin-ivb   Solution nmr   Agelenopsis aperta   Antagonist of P-type calcium channel   7703698 

Jmol
(6)5.0(3)13
 Spider   TOT1A_HADVE   1axh  R F  A   37   0.603   Actx-hvi, atracotoxin-hvi   Solution nmr   Hadronyche versuta   Inhibits insect calcium channel currents   9228949 

Jmol
(6)5.0(4)6
 Spider   TXHN1_GRARO   1d1h  R F  A   35   0.625   Hanatoxin type 1   Solution nmr   Grammostola rosea   Modifier of potassium channels   10731427 

Jmol
(6)5.0(4)9
 Spider   TJT1C_HADVE   1dl0  R F  A   37   0.794   J-atracotoxin-hv1c   Solution nmr   Synthetic   Inhibits insect potassium channels   10881200 

Jmol
(6)6.0(4)9
 Spider   TXMG1_AGEAP   1eit  R F  A   37   0.754   Mu-aga-, mu-agatoxin-i   Solution nmr   Agelenopsis aperta   Modify kinetics of insect sodium channels   8608119 

Jmol
(6)5.0(4)3
 Spider   TXHP2_HETVE   1emx  R F  A   30   1.078   Hptx2, heteropodatoxin 2   Solution nmr   Heteropoda venatoria   Bolcks kv4.2 potassium channel   11152117 

Jmol
(6)5.0(5)4
 Spider   TOT2A_HADVE   1g9p  R F  A   45   0.427   Omega-atracotoxin-hv2a   Solution nmr   Hadronyche versuta   Blocks insect calcium channels   11522785 

Jmol
(6)5.0(5)4
 Spider   TOT2A_HADVE   1hp3  R F  A   32   0.434   Ct-hv2a, omega-atracotoxin-hv2a   Solution nmr   Synthetic   Blocks insect calcium channels   11522785 

Jmol
(6)5.0(3)4
 Spider   TOT1A_HADVE   1hvw  R F  A   25   0.699   Omega-actx-hv1a, omega-atracotoxin-hv1a   Solution nmr   Synthetic   Inhibits insect calcium channel currents   11313356 

Jmol
(7)6.0(4)10
 Spider   TOG4A_AGEAP   1iva  R F  A   48   0.905   Omega-agatoxin-iva   Solution nmr   Agelenopsis aperta   Blocks P-type calcium channels   7773772 

Jmol
(6)5.0(4)8
 Spider   WGRTX_GRARO   1koz  R F  A   36   0.878   Omega-grammotoxin sia, voltage-dependent channel inhibitor   Solution nmr   Synthetic   Gating modifier of P/Q and N-type calcium channels   12162963 

Jmol
(6)7.0(4)9
 Spider   TXMO_HADIN   1kqh  R F  A   38   0.573   Actx-hi:ob4219   Solution nmr   Hadronyche infensa   Inhibits sodium channels of insects   11876637 

Jmol
(6)7.0(4)9
 Spider   TXMO_HADIN   1kqi  R F  A   38   0.645   Actx-hi:ob4219   Solution nmr   Hadronyche infensa   Inhibits sodium channels of insects   11876637 

Jmol
(6)5.0(4)6
 Spider   TX1_STRGF   1la4  R F  A   34   0.572   Voltage-gated potassium channel blocker, sgtx1   Solution nmr   Synthetic   Voltage-gated potassium channel blocker   14744131 

Jmol
(6)6.0(4)9
 Spider   TXP1_PSACA   1lmm  R F  A   40   0.742   Pctx1, psalmotoxin 1   Solution nmr   Psalmopoeus cambridgei   Specific blocker of ASIC1A Na+ channel   12824480 

Jmol
(6)6.0(5)6
 Spider   MTX4_GRARO   1lu8  R F  A   35   0.592   Gsmtx-4, venom toxin peptide mtx4   Solution nmr   Synthetic   Blocks mechanosensitive ion channels   _ 

Jmol
(6)5.0(4)3
 Spider   MTX2_GRARO   1lup  R F  A   31   1.243   Gsmtx2   Solution nmr   Grammostola rosea   inhibits mechanosensitive ion channels   12082099 

Jmol
(6)6.0(6)6
 Spider   TXH4_HAPSC   1mb6  R F  A   35   0.619   Huwentoxin-iv   Solution nmr   Ornithoctonus huwena   Acts on tetrodotoxin-sensitive sodium channels   12228241 

Jmol
(6)6.0(4)6
 Spider   H1A01_HAPHA   1nix  R F  A   34   0.453   Hainantoxin-i   Solution nmr   Ornithoctonus hainana   Binds and blocks insect sodium channels   14675784 

Jmol
(6)6.0(6)6
 Spider   H4A01_HAPHA   1niy  R F  A   36   0.489   Hntx-i, hainantoxin-iv   Solution nmr   Ornithoctonus hainana   Inhibits mammal TTX-sensitive sodium currents   15201273 

Jmol
(7)6.0(4)10
 Spider   TOG4A_AGEAP   1oav  R F  A   48   0.641   Omega-agatoxin iva   Solution nmr   Agelenopsis aperta   Blocks P-type calcium channel   7623383 

Jmol
(7)6.0(4)10
 Spider   TOG4A_AGEAP   1oaw  R F  A   48   0.627   Omega-agatoxin iva   Solution nmr   Agelenopsis aperta   Blocks P-type calcium channel   7623383 

Jmol
(7)6.0(4)10
 Spider   TOG4B_AGEAP   1oma  R F  A   48   1.059   Omega-aga-ivb   Solution nmr   Agelenopsis aperta   Antagonist of P-type calcium channels   8241166 

Jmol
(7)6.0(4)10
 Spider   TOG4B_AGEAP   1omb  R F  A   48   0.795   Omega-aga-ivb   Solution nmr   Agelenopsis aperta   Antagonist of P-type calcium channels   8241166 

Jmol
(6)5.0(4)10
 Spider   TXDT1_ATRRO   1qdp  R F  A   42   0.601   Robustoxin   Solution nmr   Atrax robustus   Slows inactivation of tetrodotoxin-sensitive sodium channels   9428632 

Jmol
(6)6.0(4)6
 Spider   TXH1_HAPSC   1qk6  R F  A   33   0.633   Huwentoxin-i   Solution nmr   Selenocosmia huwena   Binds to the nicotinic acetylcholine receptor   9263120 

Jmol
(4)5.0(4)6
 Spider   TXL1_HAPSC   1qk7  R F  A   32   0.462   Selenocosmia huwena lectin-i   Solution nmr   Selenocosmia huwena   haemagglutination   10524779 

Jmol
(6)6.0(6)6
 Spider   H4A01_HAPHA   1ryg  R F  A   36   0.501   Hntx-iv, hainantoxin-iv   Solution nmr   Synthetic   Sodium channels inhibitor   15201273 

Jmol
(6)6.0(6)6
 Spider   H4A01_HAPHA   1ryv  R F  A   36   0.451   Hntx-iv, hainantoxin-iv   Solution nmr   Synthetic   Sodium channels inhibitor   15201273 

Jmol
(6)5.0(4)6
 Spider   VSTX1_GRARO   1s6x  R F  A   34   0.429   Vstx, gating modifier toxin, kvap channel   Solution nmr   Synthetic   Gating modifier toxin   15835890 

Jmol
(6)6.0(5)6
 Spider   MTX4_GRARO   1tyk  R F  A   34   0.728   Mtx, toxin gsmtx-4   Solution nmr   Grammostola rosea   Blocks mechanosensitive ion channels   12082099 

Jmol
(6)8.0(2)4
 Spider   _   1v5a  R F  A   28   0.888   Covalitoxin-i   Solution nmr   Synthetic   _   _ 

Jmol
(6)5.0(4)3
 Spider   TXP1_PARSR   1v7f  R F  A   30   0.885   Patx1, phrixotoxin 1   Solution nmr   Synthetic   Specifically blocks Kv4.3 and Kv4.2 channels   15096626 

Jmol
(6)7.0(4)9
 Spider   TXDP1_PIRLC   1v90  R F  A   38   1.156   Delta-paluit, delta-palutoxin it1   Solution nmr   Paracoelotes luctuosus   Inhibits the inactivation of sodium activated channels on in   15726637 

Jmol
(6)7.0(4)9
 Spider   TXDP2_PIRLC   1v91  R F  A   38   0.866   Delta-paluit, delta-palutoxin it2   Solution nmr   Paracoelotes luctuosus   Inhibits the inactivation of sodium activated channels on in   15726637 

Jmol
(6)5.0(4)10
 Spider   TXDT1_HADVE   1vtx  R F  A   42   0.769   Versutoxi, delta-atracotoxin-hv1   Solution nmr   Hadronyche versuta   Slows inactivation of sodium channels   9384567 

Jmol
(6)6.0(4)4
 Spider   TXP7_APOSC   1wqb  R F  A   32   0.653   Paralytic peptide vii, pp vii, aptotoxin vii   Solution nmr   Synthetic   Paralytic and lethal to lepidopteran larvae   _ 

Jmol
(6)8.0(4)4
 Spider   TXFK1_PSACA   1x5v  R F  A   34   0.957   Pcfk1   Solution nmr   Psalmopoeus cambridgei   Strong antiplasmodial activity   16452619 

Jmol
(6)8.0(2)4
 Spider   TXH10_HAPSC   1y29  R F  A   28   0.941   Huwentoxin-x   Solution nmr   Synthetic   Blocks N-type, but not L-type, calcium channels   16439354 

Jmol
(6)6.0(4)6
 Spider   JZT7A_CHIJI   1zjq  R F  A   34   0.835   Jingzhaotoxin-vii   Solution nmr   Chilobrachys jingzhao   Toxin   _ 

Jmol
(6)5.0(4)6
 Spider   JZ11A_CHIJI   2a2v  R F  A   34   0.473   Jingzhaotoxin-xi   Solution nmr   Chilobrachys jingzhao   Toxin   17176080 

Jmol
(6)6.0(4)6
 Spider   JZT7A_CHIJI   2aap  R F  A   34   0.692   Jingzhaotoxin-vii   Solution nmr   Chilobrachys jingzhao   Toxin   _ 

Jmol
(6)7.0(4)9
 Spider   TXAG_ALLOP   2e2s  R F  A   36   0.775   Agelenin   Solution nmr   Allagelena opulenta   Insecticid, blocks the presynaptic calcium channel   17644092 

Jmol
(6)5.0(4)4
 Spider   TXMG5_MACGS   2gx1  R F  A   29   1.004   Neurotoxin magi-5   Solution nmr   Synthetic   Binds specifically to receptor site 4 on mammalian voltage-g   17148449 

Jmol
(6)6.0(4)13
 Spider   _   2h1z  R F  A   39   0.507   Hybrid atracotoxin   Solution nmr   Hadronyche versuta   ?   _ 

Jmol
(6)6.0(4)6
 Spider   JZTX3_CHIJI   2i1t  R F  A   36   1.000   Jingzhaotoxin-iii, jztx-ii, jingzhaotoxin-3   Solution nmr   Chilobrachys jingzhao   Inhibits voltage-gated sodium channels in rat cardiac myocyt   17481690 

Jmol
(6)6.0(4)6
 Spider   H3A01_HAPHA   2jtb  R F  A   33   0.852   Hainantoxin-iii, hntx-ii, hainantoxin-3   Solution nmr   Ornithoctonus hainana   Acts on mammal tetrodotoxin-sensitive voltage-gated sodium c   _ 

Jmol
(6)4.0(4)10
 Spider   TXPR1_GEOA2   2kgu  R F  A   35   0.481   Purotoxin-1   Solution nmr   Geolycosa   Inhibits P2X3 receptors   20437566 

Jmol
(6)6.0(4)9
 Spider   TXP1_PSACA   2kni  R F  A   41   0.578   Pctx1, psalmotoxin-1   Solution nmr   Psalmopoeus cambridgei   Blocks the H+-gated sodium channel ASIC1a/ACCN2   _ 

Jmol
(6)5.0(4)10
 Spider   TXMG4_MACGS   2roo  R F  A   43   0.671   Delta-hexatoxin-mg1a   Solution nmr   Synthetic   Blocks voltage-gated sodium channels   19592486 

Jmol
(6)6.0(4)6
 Spider   TXG1E_CHIJI   2wh9  R F  A   36   0.813   Gxtx-1e, gxtx1, guangxitoxin-1egxtx-1e   Solution nmr   Synthetic plesiophrictus guangxiensis   Gating modifier of Kv2.1/KCNB1, Kv2.2/KCNB2 and Kv4.3/KCND3   20509680 

Jmol
(6)5.0(3)6
 Spider   TXP3_APOSC   2m36  R F  A   38   0.704   Aps III, insecticidal spider-venom peptide   Solution nmr   Aptostichus schlingeri   Blocks insect voltage-gated sodium channels   23473802 

Jmol
(6)6.0(8)15
 Spider   TXPR2_GEOA2   2mdn  R F  A   64   0.689   Purotoxin-2   Solution nmr   Geolycosa sp. a267tdls2-kzarna   -   - 

Jmol
(6)7.0(2)19
 Spider   SFI1_SEGFL   2mf3  R F  A   47   0.917   SFI1, insecticidal spider toxin   Solution nmr   Segestria florentina   Blocks the pore of insect voltage-gated sodium channels via a large β-hairpin loop   25559770 

Jmol
(6)4.0(13)13
 Spider   TXI92_DIGCA   2mi5  R F  A   57   0.984   Mu-diguetoxin-Dc1a (Mu-DGTX-Dc1a)   Solution nmr   Diguetia canities   Interacts with the domain II voltage sensor   25014760 

Jmol
(6)6.0(6)6
 Spider   A0A0J9X1W9_9ARAC   2mpq  R F  A   36   0.606   Sodium channel toxin Hd1a   Solution nmr   Haplopelma   Modulator of the analgesic target NaV 1.7   25754331 

Jmol
(6)7.0(4)10
 Spider   TXHM3_HERML   2mqu  R F  A   35   0.606   Neurotoxin Hm-3   Solution nmr   Heriaeus melloteei   Sodium channel activation inhibitor, insecticidal peptide toxin   25352595 

Jmol
(6)6.0(4)6
 Spider   A0A0M3KKS8_9ARAC   2mt7  R F  A   35   0.470   Spider-venom peptide Hs1a   Solution nmr   Hysterocrates   -   - 

Jmol
(6)6.0(4)6
 Spider   HPR3_THRPR   2mxm  R F  A   33   0.581   Mu-theraphotoxin-Tp1a   Solution nmr   Thrixopelma pruriens   Inhibits voltage-gated sodium channels without significantly altering the voltage dependence of activation or inactivation   25979003 

Jmol
(6)11.0(3)12
 Spider   A0A0G3F8Z3_9ARAC   2myh  R F  A   41   0.537   Omega-Tbo-IT1   Solution nmr   Tibellus oblongus   Inhibitor of Insect Calcium Channels   26611444 

Jmol
(6)4.0(4)8
 Spider   TXAG4_AGEOR   2n6n  R F  A   32   0.850   U4-agatoxin-Ao1a   Solution nmr   Agelena orientalis   Ion channel inhibitor activity   - 

Jmol
(6)5.0(11)14
 Spider   A0A1D5B342_HADIN   2n6r  R F  A   76   0.691   U4-hexatoxin-Hi1a   Solution nmr   Hadronyche infensa   -   - 

Jmol
(6)6.0(14)26
 Spider   TP1A_HADIN   2n8f  R F  A   76   0.602   Pi-hexatoxin-Hi1a   Solution nmr   Hadronyche infensa   Potently and selectively inhibits ASIC1a   - 

Jmol
(6)6.0(4)6
 Spider   TX1_PSARE   5i1x  R F  A   36   0.711   F8A mutant of beta-TRTX-Pre1a   Solution nmr   Psalmopoeus reduncus   Gating-modifier toxin that both inhibits the peak current of human Nav1.1/SCN1A, rat Nav1.2/SCN2A, human Nav1.6/SCN8A, and human Nav1.7/SCN9A   - 

Jmol
(6)6.0(4)6
 Spider   TX1_PSARE   5i2p  R F  A   36   0.620   W7A mutant of mu-TRTX-Pre1a   Solution nmr   Psalmopoeus reduncus   Gating-modifier toxin that both inhibits the peak current of human Nav1.1/SCN1A, rat Nav1.2/SCN2A, human Nav1.6/SCN8A, and human Nav1.7/SCN9A   - 

Jmol
(6)5.0(4)3
 Spider   TXPR2_THRPR   5tcz  R F  A   32   1.226   Beta/omega-theraphotoxin-Tp2a   Solution nmr   Thrixopelma pruriens   Blocks both tetrodotoxin-sensitive and tetrodotoxin-resistant human voltage-gated sodium channels by shifting the voltage dependence of channel activation to more positive potentials.   28045073 

Jmol
(12)12.0(4)7
 Spider   DKTX_HAPSC   5irx  R F  E   75   0.845   Tau-theraphotoxin-Hs1a   Electron microscopy   Haplopelma schmidti (Chinese bird spider) (Ornithoctonus huwenum)   Selectively activates mammalian TRPV1, or capsaicin receptor, a nonselective cation channel expressed by sensory neurons of the pain pathway.   27281200 

Jmol
(6)5.0(4)7
 Spider   DKTX_HAPSC   2naj  R F  A   33   1.325   Tau-theraphotoxin-Hs1a, Fragment: K2 domain, UNP residues 43-75   Solution nmr   Haplopelma schmidti (Chinese bird spider) (Ornithoctonus huwenum)   Selectively activates mammalian TRPV1, or capsaicin receptor, a nonselective cation channel expressed by sensory neurons of the pain pathway.   26880553 

Jmol
(6)5.0(6)7
 Spider   DKTX_HAPSC   2n9z  R F  A   42   0.895   Tau-theraphotoxin-Hs1a, Fragment: K1 domain, UNP residues 1-42   Solution nmr   Haplopelma schmidti (Chinese bird spider) (Ornithoctonus huwenum)   Selectively activates mammalian TRPV1, or capsaicin receptor, a nonselective cation channel expressed by sensory neurons of the pain pathway.   26880553 

Jmol
(6)5.0(4)15
 Spider   SPN1A_OXYTA   2n86  R F  A   59   -   Spiderine-1a, Fragment: UNP residues 108-166   Solution nmr   Oxyopes takobius   Has antimicrobial, insecticidal, cytolytic and cytotoxic activity.   - 

Jmol
(6)9.0(4)4
 Spider   TX1_SELPU   2ll1  R F  A   33   0.640   U1-TRTX-Sp1a   Solution nmr   Selenotypus plumipes (Australian featherleg tarantula)   Probable ion channel inhibitor. Shows insecticidal activity. Acts synergistically with the neonicotinoid insecticide imidacloprid.   - 

Jmol
(5)4.0(13)9
 Spider   Q4PN35_IXOSC   2ndi  R F  A   46   -   Putative secreted salivary protein   Solution nmr   Ixodes scapularis (Black-legged tick) (Deer tick)   Selective inhibitor of the Nav1.7 channel   27407029 

Jmol
(6)6.0(4)6
 Spider   JZT7A_CHIGU   1zjq  R F  A   34   0.796   U1-theraphotoxin-Cg1a 1   Solution nmr   Chilobrachys guangxiensis   Probable ion channel inhibitor.   - 

To display Sequence alignments OR Jmol Structural superimpositions of selected knottins:
1 - Use the checkboxes to make selection or use the 'Select All' button
2 - Choose either a 1D Sequence alignment or a 3D Structural superimposition

Sponge

4 three-dimensional structure of Sponge knottins


To display Sequence alignments OR Jmol Structural superimpositions of selected knottins:
1 - Use the checkboxes to make selection or use the 'Select All' button
2 - Choose either a 1D Sequence alignment or a 3D Structural superimposition
 
 Nomenclature   Family   SwissProt   PDBsum   Chain   Length   RMS   Descriptor   Experimental   Source   Function   PubMed 

Jmol
(6)6.0(6)8
 Sponge   I1SB10_9METZ   3q8j  R F  A   37   0.697   Asteropsin A   Solution nmr   Asteropus sp.   Enhances Ca2+ influx in murine cerebrocortical neuron cells   - 

Jmol
(6)6.0(6)8
 Sponge   I1SB10_9METZ   2lqa  R F  A   37   0.761   Asteropsin A   Solution nmr   Asteropus sp.   Enhances Ca2+ influx in murine cerebrocortical neuron cells   23201194 

Jmol
(6)6.0(4)8
 Sponge   I1SB10_9METZ   2m3j  R F  A   33   0.813   Asteropsin E   Solution nmr   Asteropus   -   - 

Jmol
(6)6.0(4)8
 Sponge   A0A1A9T938_9METZ   2n2g  R F  A   33   0.743   Asteropsin_F   Solution nmr   Asteropus   -   - 

To display Sequence alignments OR Jmol Structural superimpositions of selected knottins:
1 - Use the checkboxes to make selection or use the 'Select All' button
2 - Choose either a 1D Sequence alignment or a 3D Structural superimposition

Trematoda

0 three-dimensional structure of Trematoda knottins

 
 


Trichoplax

0 three-dimensional structure of Trichoplax knottins

 
 


Virus1

2 three-dimensional structures of Virus1 knottins


To display Sequence alignments OR Jmol Structural superimpositions of selected knottins:
1 - Use the checkboxes to make selection or use the 'Select All' button
2 - Choose either a 1D Sequence alignment or a 3D Structural superimposition
 
 Nomenclature   Family   SwissProt   PDBsum   Chain   Length   RMS   Descriptor   Experimental   Source   Function   PubMed 

Jmol
(6)6.0(16)7
 Virus1   Q89632_CSIV   1xi7  R F  A   61   0.931   Vhv1.1 protein, cysteine-rich omega-conotoxin homolog vhv1.1   Solution nmr   Campoletis sonorensis ichnovirus   _   11724552 

Jmol
(6)6.0(16)7
 Virus1   Q89632_CSIV   1xj1  R F  A   61   0.823   Vhv1.1 protein, cysteine-rich omega-conotoxin homolog vhv1.1   Solution nmr   Campoletis sonorensis ichnovirus   _   11724552 

To display Sequence alignments OR Jmol Structural superimpositions of selected knottins:
1 - Use the checkboxes to make selection or use the 'Select All' button
2 - Choose either a 1D Sequence alignment or a 3D Structural superimposition

Virus2

0 three-dimensional structure of Virus2 knottins

 
 


Water flea

0 three-dimensional structure of Water flea knottins