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Experimental 3D structures

Below are fixed pre-compiled database outputs

Agouti-related	Alpha-amylase inhibitor	Algae	Bacteria	Bug
Ciliate	Conotoxin1	Conotoxin2	Conotoxin3	Cyclotide
Fungi1	Fungi2	Gurmarin-like	Horseshoe crab	Insect1
Insect2	Maize	Metallocarboxypeptidase inhibitor	Mycetozoa	Plant antimicrobial
Plant defensin	Plant toxin	Plant toxin2	Scorpion1	Scorpion2
Serine protease inhibitor1	Serine protease inhibitor2	Serine protease inhibitor3	Spider	Sponge
Trematoda	Trichoplax	Virus1	Virus2	Water flea

Please note the link significations in the following table
	points at individual protein cards (structural data, "Colliers de Perles" ...)
Jmol	runs the Jmol viewing applet (loops '(a)', 'b', 'c', '(d)' and 'e' are colored green, salmon, aquamarine, light blue and pink, respectively
R	points at renumbered PDB files according to the knottin unique numbering
F	points at structurally fitted PDB files (useful for easy 3D comparisons)
	Note: superimposed PDBs and/or 3D models can be viewed (Jmol) using the checkboxes and the form below

Agouti-related

5 three-dimensional structures of Agouti-related knottins

To display Sequence alignments OR Jmol Structural superimpositions of selected knottins:
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	Nomenclature	Family	SwissProt	PDBsum	Chain	Length	RMS	Descriptor	Experimental	Source	Function	PubMed
	Jmol (6)6.0(5)10	Agouti-related	AGRP_HUMAN	1hyk  R F	A	46	0.783	Agouti related protein	Solution nmr	Synthetic	Appetite-stimulating	10371151
	Jmol (6)6.0(5)10	Agouti-related	AGRP_HUMAN	1mr0  R F	A	34	1.071	Agouti related protein	Solution nmr	Synthetic	Appetite-stimulating	12056887
	Jmol (6)6.0(5)10	Agouti-related	ASIP_HUMAN	1y7j  R F	A	53	1.154	Agouti switch protein, agouti signaling protein	Solution nmr	Synthetic	Involved in the regulation of melanogenesis	15701517
	Jmol (6)6.0(5)10	Agouti-related	ASIP_HUMAN	1y7k  R F	A	53	1.207	Agouti switch protein, agouti signaling protein	Solution nmr	Synthetic	Involved in the regulation of melanogenesis	15701517
	Jmol (6)6.0(5)10	Agouti-related	ASIP_HUMAN	2kza  R F	A	53	1.154	Asp, agouti switch protein, agouti-signaling protein	Solution nmr	Synthetic homo sapiens	Involved in the regulation of melanogenesis. May affect the	20831872

To display Sequence alignments OR Jmol Structural superimpositions of selected knottins:
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Alpha-amylase inhibitor

7 three-dimensional structures of Alpha-amylase inhibitor knottins

To display Sequence alignments OR Jmol Structural superimpositions of selected knottins:
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	Nomenclature	Family	SwissProt	PDBsum	Chain	Length	RMS	Descriptor	Experimental	Source	Function	PubMed
	Jmol (6)8.0(4)7	Alpha-amylase inhibitor	IAAI_AMAHP	1clv  R F	I	32	0.386	Alpha-amylas	X-ray diffraction	Synthetic	Insect alpha-amylase inhibitor	10508777
	Jmol (6)8.0(4)7	Alpha-amylase inhibitor	IAAI_AMAHP	1htx  R F	A	32	0.826	Alpha-amylase inhibitor aai	Solution nmr	Amaranthus hypochondriacus	Insect alpha-amylase inhibitor	11298757
	Jmol (6)8.0(4)7	Alpha-amylase inhibitor	IAAI_AMAHP	1qfd  R F	A	32	0.903	Alpha-amylas	Solution nmr	Amaranthus hypochondriacus	Insect alpha-amylase inhibitor	10400675
	Jmol (6)6.0(4)7	Alpha-amylase inhibitor	U5JE23_ALLCA	2mi9  R F	A	30	0.939	Allotide C4, conformation 1	Solution nmr	Allamanda cathartica	Sequence homology places Ec-AMP1 in the plant C6-type of antimicrobial peptides, but the three dimensional structure is highly similar to that of a spider neurotoxin	25832441
	Jmol (6)6.0(4)7	Alpha-amylase inhibitor	U5JE23_ALLCA	2mia  R F	A	30	0.965	Allotide C4, conformation 2	Solution nmr	Allamanda cathartica	Sequence homology places Ec-AMP1 in the plant C6-type of antimicrobial peptides, but the three dimensional structure is highly similar to that of a spider neurotoxin	25832441
	Jmol (6)5.0(4)8	Alpha-amylase inhibitor	V5W9K8_9GENT	4bfh  R F	A	30	0.351	Alpha amylase inhibitor Wrightide R1	X-ray	Wrightia religiosa	May bind to insect α-amylase via a different set of interactions	25040200
	Jmol (6)5.0(4)8	Alpha-amylase inhibitor	V5W9K8_9GENT	2mau  R F	A	30	0.752	Alpha-amylase inhibitor wrightide R1 (wR1)	Solution nmr	Wrightia religiosa	May bind to insect α-amylase via a different set of interactions	25040200

To display Sequence alignments OR Jmol Structural superimpositions of selected knottins:
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Algae

0 three-dimensional structure of Algae knottins

Bacteria

0 three-dimensional structure of Bacteria knottins

Bug

2 three-dimensional structures of Bug knottins

To display Sequence alignments OR Jmol Structural superimpositions of selected knottins:
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	Nomenclature	Family	SwissProt	PDBsum	Chain	Length	RMS	Descriptor	Experimental	Source	Function	PubMed
	Jmol (6)6.0(5)6	Bug	PTU1_PEITU	1i26  R F	A	34	0.826	Ptu-1	Solution nmr	Peirates turpis	Blocks N-type calcium channel	11669615
	Jmol (6)6.0(4)6	Bug	ADO1_AGRDO	1lmr  R F	A	35	1.078	Toxin ado1	Solution nmr	Agriosphodrus dohrni	Binds reversibly and blocks N-type voltage-gated calcium cha	14696181

To display Sequence alignments OR Jmol Structural superimpositions of selected knottins:
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Ciliate

0 three-dimensional structure of Ciliate knottins

Conotoxin1

38 three-dimensional structures of Conotoxin1 knottins

To display Sequence alignments OR Jmol Structural superimpositions of selected knottins:
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	Nomenclature	Family	SwissProt	PDBsum	Chain	Length	RMS	Descriptor	Experimental	Source	Function	PubMed
	Jmol (6)3.0(4)7	Conotoxin1	CGS_CONGE	1ag7  R F	A	34	0.642	Conotoxin gs	Solution nmr	Conus geographus	Inhibits sodium channel	9115446
	Jmol (6)6.0(3)5	Conotoxin1	CO17A_CONPU	1av3  R F	A	27	0.701	Kappa-pviia	Solution nmr	Conus purpurascens	Blocks potassium channel	9438859
	Jmol (6)6.0(3)5	Conotoxin1	CO7C_CONMA	1cnn  R F	A	27	0.683	Mviic, omega-conotoxin mviic	Solution nmr	Synthetic	Blocks P/Q-type calcium channel	10373375
	Jmol (6)6.0(3)4	Conotoxin1	CO17A_CONMA	1dw4  R F	A	26	0.851	Omega-conotoxin mviia	Solution nmr	Synthetic	Blocks N-type calcium channel	10747778
	Jmol (6)6.0(3)4	Conotoxin1	CO17A_CONMA	1dw5  R F	A	26	0.986	Omega-conotoxin mviia	Solution nmr	Synthetic	Blocks N-type calcium channel	10747778
	Jmol (6)3.0(4)4	Conotoxin1	C7A_CONTU	1eyo  R F	A	30	0.874	Conotoxin tviia	Solution nmr	Synthetic	May inhibit sodium channel	10903497
	Jmol (6)6.0(3)3	Conotoxin1	CO7_CONTE	1f3k  R F	A	26	0.851	Omega-conotoxin txvii	Solution nmr	Synthetic	Blocks L-type calcium channel	11101291
	Jmol (6)6.0(3)4	Conotoxin1	CO17A_CONMA	1feo  R F	A	26	0.976	Omega-conotoxin mviia-gly	Solution nmr	Synthetic	Blocks N-type calcium channel	11344322
	Jmol (6)6.0(3)4	Conotoxin1	CO16A_CONTE	1fu3  R F	A	27	0.455	Txia, conotoxin king-kong 0, kk-0, delta-conotoxin txvia	Solution nmr	Synthetic	Inhibits sodium current inactivation	12145313
	Jmol (6)6.0(3)4	Conotoxin1	CO13_CONST	1fyg  R F	A	25	0.889	Omega conotoxin so3	Solution nmr	Synthetic	Inhibits calcium channel	_
	Jmol (6)9.0(3)3	Conotoxin1	CO6A_CONER	1g1p  R F	A	33	0.441	Conotoxin evia	Solution nmr	Synthetic	Inhibits neuronal sodium channel	14976206
	Jmol (6)9.0(3)3	Conotoxin1	CO6A_CONER	1g1z  R F	A	33	0.640	Conotoxin evia	Solution nmr	Synthetic	Blocks mu1 sodium channel	14976206
	Jmol (6)6.0(3)5	Conotoxin1	CO17A_CONPU	1kcp  R F	A	28	0.683	Kappa-conotoxin pviia	Solution nmr	Conus purpurascens	Inhibits the shaker potassium channel	9548922
	Jmol (6)6.0(3)4	Conotoxin1	CO17A_CONMA	1mvi  R F	A	26	0.849	Omega-conotoxin mviia, mviia	Solution nmr	Conus magus	Blocks N-type calcium channel	8913308
	Jmol (6)6.0(3)5	Conotoxin1	CO16B_CONST	1mvj  R F	A	27	0.855	Omega-conotoxin svib, svib	Solution nmr	Conus striatus	Blocks N-type calcium channel	8913308
	Jmol (6)6.0(2)6	Conotoxin1	CO16A_CONGE	1omc  R F	A	28	0.745	Omega-conotoxin gvia	Solution nmr	Conus geographus	Blocks N-type calcium channel	8338837
	Jmol (6)6.0(3)4	Conotoxin1	CO17A_CONMA	1omg  R F	A	26	0.765	Omega-conotoxin mviia	Solution nmr	Conus magus	Blocks N-type calcium channel	7640281
	Jmol (6)6.0(3)5	Conotoxin1	CO7C_CONMA	1omn  R F	A	27	0.883	Snx-23, omega-conotoxin m vii c (m seven c)	Solution nmr	Conus magus	Blocks P/Q type calcium channel	7731037
	Jmol (6)9.0(4)4	Conotoxin1	CO16B_CONMR	1rmk  R F	A	31	0.754	Mu-o-conotoxin mrvib	Solution nmr	Conus marmoreus	Blocks voltage-sensitive sodium channel and fast-inactivatin	15044438
	Jmol (6)6.0(2)6	Conotoxin1	CO16A_CONGE	1tr6  R F	A	28	0.836	Omega-conotoxin gvia	Solution nmr	Conus geographus	Blocks N-type calcium channels	15166237
	Jmol (6)6.0(3)4	Conotoxin1	CO17A_CONMA	1tt3  R F	A	26	0.821	Omega-conotoxin [k10]mviia, omega-conotoxin mviia	Solution nmr	Synthetic	Blocks N-type calcium channels	12441339
	Jmol (6)6.0(3)4	Conotoxin1	CO17A_CONMA	1ttk  R F	A	26	0.560	Omega-conotoxin mviia	Solution nmr	Synthetic	Blocks N-type calcium channels	12441339
	Jmol (6)6.0(2)6	Conotoxin1	CO16A_CONGE	1ttl  R F	A	28	0.981	Omega-conotoxin gvia	Solution nmr	Conus geographus	Blocks N-type calcium channels	15166237
	Jmol (6)6.0(3)5	Conotoxin1	CO7C_CONMA	1v4q  R F	A	27	0.543	Omega-conotoxin mviic	Solution nmr	Synthetic	Blocks N-type calcium channels and some types of high-thresh	_
	Jmol (6)6.0(3)3	Conotoxin1	CO66_CONAA	1yz2  R F	A	27	1.492	Delta-conotoxin am 2766	Solution nmr	Conus amadis	Inhibits the inactivation of voltage-sensitive sodium channe	_
	Jmol (6)6.0(2)6	Conotoxin1	CO16A_CONGE	2cco  R F	A	28	0.822	Omega-conotoxin gvia	Solution nmr	Conus geographus	Blocks N-type calcium channel	10231724
	Jmol (6)5.0(2)4	Conotoxin1	CI1BA_CONRA	2jry  R F	A	46	0.983	R11., i-superfamily conotoxin r11a	Solution nmr	Conus radiatus	Binds sodium channels and affects their activation	17696362
	Jmol (6)5.0(2)4	Conotoxin1	CI1BA_CONRA	2jtu  R F	A	38	1.187	R11.6, i-superfamily conotoxin r11a	Solution nmr	Synthetic	Binds sodium channels (Nav1.6/SCN8A)	_
	Jmol (6)6.0(3)4	Conotoxin1	_	2km9  R F	A	25	0.910	Omega_conotoxin-fvia	Solution nmr	Synthetic	Blocks N-type calcium channel	PMED
	Jmol (6)5.0(2)4	Conotoxin1	CI1BA_CONRA	2p4l  R F	A	46	1.153	R11.6, conotoxin iota-rxia, i-superfamily conotoxin r11a	Solution nmr	Conus radiatus	Binds sodium channels and affects their activation	17696362
	Jmol (0)6.3(5)0	Conotoxin1	CM3B_CONBU	2lo9  R F	A	25	2.614	Mu-contoxin BuIIIB	Solution nmr	Conus bullatus	Mammalian neuronal sodium channel blocker	23557677
	Jmol (0)6.3(5)0	Conotoxin1	CM3B_CONBU	2loc  R F	A	25	2.531	[d-Ala2]BuIIIB contoxin	Solution nmr	Conus bullatus	Mammalian neuronal sodium channel blocker	23557677
	Jmol (0)1.4(5)0	Conotoxin1	CM3A_CONKI	2lxg  R F	A	17	-	Mu-conotoxin KIIIA	Solution nmr	Conus kinoshitai	Potent blocker of Na(V)1.2	23167564
	Jmol (6)9.0(4)4	Conotoxin1	A0A0K2SEF6_CONEP	2n7f  R F	A	32	0.910	MuO-conotoxin MfVIA	Solution nmr	Synthetic construct	Inhibits the voltage-gated sodium channel NaV1.8	27026701
	Jmol (6)6.0(3)6	Conotoxin1	CO17J_CONGE	2n8h  R F	A	35	0.790	Mu-conotoxin GVIIJ	Solution nmr	Conus geographus	Blocks voltage-gated sodium channels (Nav)	26817840
	Jmol (0)5.4(5)0	Conotoxin1	GM3C_CONCN	2yen  R F	A	23	2.365	Mu-conotoxin CnIIIC	Solution nmr	Conus consors	Blocks voltage-gated sodium channels (Nav)	22229737
	Jmol (0)7.2(1)3	Conotoxin1	CEX_CONCN	4b1q  R F	P	30	-	Conotoxin CcTx (O-Glycosylated Conopeptide Cctx)	Solution nmr	Conus consors	May specifically activate neuronal voltage-gated sodium channels (Nav) at the resting membrane potential.	23281027
	Jmol (6)6.0(3)5	Conotoxin1	CO17A_CONPU	2n8e  R F	A	34	1.194	Kappa-conotoxin PVIIA	Solution nmr	Conus purpurascens	This toxin inhibits the Shaker channel from insects.	27093300

To display Sequence alignments OR Jmol Structural superimpositions of selected knottins:
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Conotoxin2

3 three-dimensional structure of Conotoxin2 knottins

To display Sequence alignments OR Jmol Structural superimpositions of selected knottins:
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	Nomenclature	Family	SwissProt	PDBsum	Chain	Length	RMS	Descriptor	Experimental	Source	Function	PubMed
	Jmol (3)5.3(1)4	Conotoxin2	CP91_CONGL	1ixt  R F	A	27	0.929	Spasmodic protein tx9a-like protein	Solution nmr	Synthetic	Unknown	12193600
	Jmol (3)5.3(1)4	Conotoxin2	CP91_CONGL	2mso  R F	A	30	-	Conotoxin Gm9.1	Solution nmr	Conus gloriamaris	"Elicits ""spasmodic"" symptomatology."	26172377
	Jmol (3)3.3(1)4	Conotoxin2	CP91_CONGL	2msq  R F	A	27	0.914	Conotoxin cBru9a	Solution nmr	Synthetic construct	-	26172377

To display Sequence alignments OR Jmol Structural superimpositions of selected knottins:
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Conotoxin3

0 three-dimensional structure of Conotoxin3 knottins

Cyclotide

35 three-dimensional structures of Cyclotide knottins

To display Sequence alignments OR Jmol Structural superimpositions of selected knottins:
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	Nomenclature	Family	SwissProt	PDBsum	Chain	Length	RMS	Descriptor	Experimental	Source	Function	PubMed
	Jmol (3)4.6(1)4[6]	Cyclotide	CIRA_CHAPA	1bh4  R F	A	30	1.016	Circulin a	Solution nmr	Chassalia parviflora	anti-HIV	9878410
	Jmol (4)7.1(4)5[5]	Cyclotide	CYO1_VIOOD	1df6  R F	A	30	1.343	Cycloviolacin o1	Solution nmr	Viola odorata	Cytotoxic	10600388
	Jmol (0)0.0(0)0[7]	Cyclotide	KAB1_OLDAF	1jjz  R F	A	29	1.407	Kalata b1	Solution nmr	Oldenlandia affinis	Uterotonic	11888199
	Jmol (0)0.0(0)0[7]	Cyclotide	KAB1_OLDAF	1k48  R F	A	29	1.487	Kalata b1	Solution nmr	Oldenlandia affinis	Uterotonic	11888199
	Jmol (7)3.4(4)1[7]	Cyclotide	KAB1_OLDAF	1kal  R F	A	29	1.206	Kalata b1	Solution nmr	Oldenlandia affinis	Uterotonic	7703226
	Jmol (3)4.4(1)4[7]	Cyclotide	KAB1_OLDAF	1nb1  R F	A	29	0.956	Kalata b1	Solution nmr	Oldenlandia affinis	Uterotonic	12482868
	Jmol (3)4.7(1)4[5]	Cyclotide	CYO1_VIOOD	1nbj  R F	A	30	1.081	Cycloviolacin o1	Solution nmr	Viola odorata	Cytotoxic	12482868
	Jmol (3)4.4(1)4	Cyclotide	KAB1_OLDAF	1orx  R F	A	24	1.087	Kalata b1	Solution nmr	Synthetic	Loss of hemolytic activity compared to native peptide	12779323
	Jmol (3)4.4(1)4[7]	Cyclotide	KAB2_OLDAF	1pt4  R F	A	29	1.184	Kalata b2	Solution nmr	Oldenlandia affinis	Probably participates in a plant defense mechanism	15654741
	Jmol (3)5.7(1)7[8]	Cyclotide	PALIC_PALCO	1r1f  R F	A	37	1.392	Palicourein	Solution nmr	Palicourea condensata	Anti-HIV	14725768
	Jmol (3)4.7(1)4[5]	Cyclotide	VHR1_VIOHE	1vb8  R F	A	30	1.202	Vhr, viola hederacea root peptide 1	Solution nmr	Viola hederacea	Probably participates in a plant defense mechanism	15295104
	Jmol (3)4.4(1)5[10]	Cyclotide	TRIC_VIOAR	1yp8  R F	A	33	1.211	Tricyclon a	Solution nmr	Viola tricolor	-	15893660
	Jmol (3)5.6(1)4[6]	Cyclotide	VHL1_VIOHE	1za8  R F	A	31	0.917	Vhl-1	Solution nmr	Viola hederacea	Probably involved in plant defense. Has antiviral activity	15824119
	Jmol (3)4.4(1)4[7]	Cyclotide	KAB4_OLDAF	1znu  R F	A	29	1.091	Kalata b1	Solution nmr	Oldenlandia affinis	Uterotonic. Probably involved in plant defense	16817894
	Jmol (3)4.4(1)5[8]	Cyclotide	KAB8_OLDAF	2b38  R F	A	31	1.160	Kalata b8	Solution nmr	Oldenlandia affinis	Probably involved in plant defense. Has antiviral activity	16207177
	Jmol (3)4.6(1)4[7]	Cyclotide	CIRB_CHAPA	2eri  R F	A	31	0.826	Cirb, circulin b	Solution nmr	Chassalia parviflora	Probably involved in plant defense. Antiviral and antibiotic	_
	Jmol (3)4.4(1)4[7]	Cyclotide	KAB1_OLDAF	2f2i  R F	A	29	1.030	Kalata-b1	Solution nmr	Synthetic	_	16300479
	Jmol (3)4.4(1)4[7]	Cyclotide	KAB1_OLDAF	2f2j  R F	A	29	1.105	Kalata-b1	Solution nmr	Synthetic	_	16300479
	Jmol (3)4.4(1)4	Cyclotide	VIOLA_VIOOD	2fqa  R F	A	27	1.768	Violacin , violacin 1	Solution nmr	Viola odorata	Reduced hemolytic activity vs cyclotides	16488428
	Jmol (3)4.4(1)5[8]	Cyclotide	CYO14_VIOOD	2gj0  R F	A	31	1.159	Cycloviolacin o14	Solution nmr	Viola odorata	_	16872274
	Jmol (3)4.4(1)4[7]	Cyclotide	KAB7_OLDAF	2jwm  R F	A	29	1.157	Kalata-b7	Solution nmr	Oldenlandia affinis	Probably involved in plant defense. Hemolytic.	18295894
	Jmol (3)4.4(1)4[7]	Cyclotide	VARF_VIOAR	2k7g  R F	A	29	0.911	Varv peptide f	Solution nmr	Viola arvensis	Probably participates in a plant defense mechanism, Cytotoxi	19211551
	Jmol (3)4.6(1)4[6]	Cyclotide	CYO2_VIOOD	2kcg  R F	A	30	1.243	Cycloviolacin-o2	Solution nmr	Viola odorata	Probably participates in a plant defense mechanism. Cytotoxi	-
	Jmol (3)4.4(1)4[7]	Cyclotide	KAB2_OLDAF	2kch  R F	A	29	1.123	Kalata-b2	Solution nmr	Oldenlandia affinis	Probably participates in a plant defense mechanism. Insectic	-
	Jmol (3)4.4(1)4	Cyclotide	KAB1_OLDAF	2khb  R F	A	29	0.971	Linear kalata-b1	Solution nmr	Oldenlandia affinis	_	_
	Jmol (3)4.6(1)4	Cyclotide	CYO2_VIOOD	2knm  R F	A	30	0.692	Cycloviolacin-o2	Solution nmr	Viola odorata	Cytotoxic, hemolytic	19735083
	Jmol (3)4.4(1)5	Cyclotide	VHL2_VIOHE	2kuk  R F	A	30	1.243	Vhl-2, leaf cyclotide 2	Solution nmr	Viola hederacea	Probably participates in a plant defense mechanism. Has hemo	_
	Jmol (3)4.6(1)4	Cyclotide	KAB5_OLDAF	2kux  R F	A	30	1.232	Kalata-b5	Solution nmr	Oldenlandia affinis	Probably involved in plant defense	20564013
	Jmol (3)4.4(1)4	Cyclotide	KAB12_OLDAF	2kvx  R F	A	28	0.924	Kalata-b12	Solution nmr	Synthetic oldenlandia affinis	Probably participates in a plant defense mechanism	_
	Jmol (3)4.4(1)4	Cyclotide	_	2lam  R F	A	29	0.958	Cyclotide cter m	Solution nmr	Synthetic clitoria ternatea	Probably participates in a plant defense mechanism. Has inse	21593408
	Jmol (3)4.4(1)4[7]	Cyclotide	VARF_VIOAR	3e4h  R F	A	29	0.906	Varv peptide f	X-ray diffraction	Viola arvensis	Probably participates in a plant defense mechanism. Cytotoxi	19211551
	Jmol (3)4.4(1)4	Cyclotides	KAB4_OLDAF	2lur  R F	A	29	1.785	KB1(GHFRWG;23-28), synthesized melanocortin analogue of kalata B1	Solution nmr	Synthetic	Selective MC4R (melanocortin receptor 4) agonist	23012369
	Jmol (3)4.4(1)4	Cyclotides	KAB7_OLDAF	2m9o  R F	A	29	0.845	Oxytocic plant peptide kalata B7	Solution nmr	Oldenlandia affinis	Probably participates in a plant defense mechanism. Has hemolytic activity.	24248349
	Jmol (3)4.4(1)4	Cyclotides	KAB1_OLDAF	2mh1  R F	A	33	1.033	Kalata-B1, Fragment: UNP Residues 93-120	Solution nmr	Oldenlandia affinis	Probably participates in a plant defense mechanism. Has antibiotic activity. Has a diuretic effect. Has a uterotonic effect in humans.	24425873
	Jmol (3)4.4(1)5	Cyclotides	KAB1_OLDAF	2mn1  R F	A	30	0.973	kalata B1[W23WW]	Solution nmr	Oldenlandia affinis	Probably participates in a plant defense mechanism. Has antibiotic activity. Has a diuretic effect. Has a uterotonic effect in humans.	25099014

To display Sequence alignments OR Jmol Structural superimpositions of selected knottins:
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2 - Choose either a 1D Sequence alignment or a 3D Structural superimposition

Fungi1

0 three-dimensional structure of Fungi1 knottins

Fungi2

0 three-dimensional structure of Fungi2 knottins

Gurmarin-like

2 three-dimensional structures of Gurmarin-like knottins

To display Sequence alignments OR Jmol Structural superimpositions of selected knottins:
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	Nomenclature	Family	SwissProt	PDBsum	Chain	Length	RMS	Descriptor	Experimental	Source	Function	PubMed
	Jmol (6)6.0(4)9	Gurmarin-like	GUR_GYMSY	1c4e  R F	A	35	1.198	Gurmarin	Solution nmr	Gymnema sylvestre	Sweet taste suppressing	10491100
	Jmol (0)0.0(0)0	Gurmarin-like	GUR_GYMSY	1gur  R F	A	35	1.119	Gurmarin	Solution nmr	Gymnema sylvestre	Sweet taste suppressing	7787425

To display Sequence alignments OR Jmol Structural superimpositions of selected knottins:
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Horseshoe crab

3 three-dimensional structures of Horseshoe crab knottins

To display Sequence alignments OR Jmol Structural superimpositions of selected knottins:
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	Nomenclature	Family	SwissProt	PDBsum	Chain	Length	RMS	Descriptor	Experimental	Source	Function	PubMed
	Jmol (6)11.0(4)11	Horseshoe crab	TACA2_TACTR	1cix  R F	A	44	1.011	Tachystati	Solution nmr	Tachypleus tridentatus	Antimicrobial	11959852
	Jmol (6)7.0(4)11	Horseshoe crab	TACB1_TACTR	2dcv  R F	A	42	0.767	Tachystatin-b1	Solution nmr	Tachypleus tridentatus	Antimicrobial, binds to chitin	17394123
	Jmol (6)7.0(4)11	Horseshoe crab	TACB2_TACTR	2dcw  R F	A	42	0.730	Tachystatin-b2	Solution nmr	Tachypleus tridentatus	Antimicrobial, binds to chitin	17394123

To display Sequence alignments OR Jmol Structural superimpositions of selected knottins:
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Insect1

1 three-dimensional structure of Insect1 knottins

To display Sequence alignments OR Jmol Structural superimpositions of selected knottins:
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	Nomenclature	Family	SwissProt	PDBsum	Chain	Length	RMS	Descriptor	Experimental	Source	Function	PubMed
	Jmol (6)8.0(3)10	Insect1	ALO3_ACRLO	1q3j  R F	A	36	0.881	Alo3	Solution nmr	Synthetic	Antifungal protein	14661954

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Insect2

0 three-dimensional structure of Insect2 knottins

Maize

0 three-dimensional structure of Maize knottins

Metallocarboxypeptidase inhibitor

3 three-dimensional structures of Metallocarboxypeptidase inhibitor knottins

To display Sequence alignments OR Jmol Structural superimpositions of selected knottins:
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	Nomenclature	Family	SwissProt	PDBsum	Chain	Length	RMS	Descriptor	Experimental	Source	Function	PubMed
	Jmol (3)5.5(2)6	Metallocarboxypeptidase inhibitor	MCPI_SOLTU	1h20  R F	A	39	0.967	Carboxypeptidase inhibitor, mcpi, metallocarboxypeptidase inhibitor	Solution nmr	Solanum tuberosum	Carboxypeptidase A inhibitor	12557184
	Jmol (3)5.5(2)13	Metallocarboxypeptidase inhibitor	FSPM_SOLLC	2hlg  R F	A	39	0.939	Fruit-specific protein	Solution nmr	Lycopersicon esculentum	_	_
	Jmol (3)5.5(2)6	Metallocarboxypeptidase inhibitor	MCPI_SOLTU	4cpa  R F	I	38	0.924	Metallocarboxypeptidase inhibitor	X-ray diffraction	Solanum tuberosum	Carboxypeptidase A inhibitor	7154070

To display Sequence alignments OR Jmol Structural superimpositions of selected knottins:
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Mycetozoa

0 three-dimensional structure of Mycetozoa knottins

Plant antimicrobial

2 three-dimensional structure of Plant antimicrobial knottins

To display Sequence alignments OR Jmol Structural superimpositions of selected knottins:
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	Nomenclature	Family	SwissProt	PDBsum	Chain	Length	RMS	Descriptor	Experimental	Source	Function	PubMed
	Jmol (6)8.0(3)10	Plant antimicrobial	PAFP_PHYAM	1dkc  R F	A	38	0.683	Pafp-, antifungal peptide	Solution nmr	Phytolacca americana	Antifungal	11551192
	Jmol (6)6.0(4)4	Plant antimicrobial	A0A1S4NYD9_9ROSI	5gsf  R F	A	27	1.252	Roseltide rT1	Solution nmr	Hibiscus sabdariffa	Roseltide rT1 was shown to inhibit human neutrophil elastase using enzymatic and pull-down assays.	27991569

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Plant defensin

1 three-dimensional structure of Plant defensin knottins

To display Sequence alignments OR Jmol Structural superimpositions of selected knottins:
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	Nomenclature	Family	SwissProt	PDBsum	Chain	Length	RMS	Descriptor	Experimental	Source	Function	PubMed
	Jmol (6)5.2(10)6	Plant defensin	DEF1_PETHY	1n4n  R F	A	47	0.910	Phd, floral defensin-like protein 1	Solution nmr	Petunia x hybrida	Floral defensin-like protein 1	12846570

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Plant toxin

2 three-dimensional structures of Plant toxin knottins

To display Sequence alignments OR Jmol Structural superimpositions of selected knottins:
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	Nomenclature	Family	SwissProt	PDBsum	Chain	Length	RMS	Descriptor	Experimental	Source	Function	PubMed
	Jmol (3)7.4(1)9	Plant toxin	ALB1_SOYBN	1ju8  R F	A	37	0.976	Albumin 1, leginsulin	Solution nmr	Synthetic	Stimulates phosphorylation of the plant insulin-binding prot	12631285
	Jmol (3)7.4(1)9	Plant toxin	ALB1F_PEA	1p8b  R F	A	37	1.231	Pa1b, albumin a1b, leginsuli, pea albumin 1, subunit b	Solution nmr	Pisum sativum	binds to basic 7S globulin (BG) and stimulates its phosphory	14556622

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Plant toxin2

1 three-dimensional structures of Plant toxin knottins

To display Sequence alignments OR Jmol Structural superimpositions of selected knottins:
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	Nomenclature	Family	SwissProt	PDBsum	Chain	Length	RMS	Descriptor	Experimental	Source	Function	PubMed
	Jmol (4)5.3(1)10	Plant toxin2	D0VWX1_MOMCO	2knp  R F	A	33	1.474	Mcocc-1	Solution nmr	Momordica cochinchinensis	Cytotoxic	19711988

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Scorpion1

2 three-dimensional structures of Scorpion1 knottins

To display Sequence alignments OR Jmol Structural superimpositions of selected knottins:
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	Nomenclature	Family	SwissProt	PDBsum	Chain	Length	RMS	Descriptor	Experimental	Source	Function	PubMed
	Jmol (6)5.0(3)10	Scorpion1	SCXC_SCOMA	1c6w  R F	A	33	0.887	Mca, maurocalcin	Solution nmr	Synthetic	Acts on a ryanodine-sensitive calcium channel	10861934
	Jmol (6)5.0(3)10	Scorpion1	IPTXA_PANIM	1ie6  R F	A	33	0.609	Peptide neurotoxin, ryanodine receptor activator, imperatoxin a	Solution nmr	Synthetic	Ryanodine receptor activator	14535845

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Scorpion2

4 three-dimensional structures of Scorpion2 knottins

To display Sequence alignments OR Jmol Structural superimpositions of selected knottins:
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	Nomenclature	Family	SwissProt	PDBsum	Chain	Length	RMS	Descriptor	Experimental	Source	Function	PubMed
	Jmol (2)10.2(8)4	Scorpion2	SCXL_LEIQU	1chl  R F	A	36	1.127	Chlorotoxin	Solution nmr	Leiurus quinquestriatus	Blocks chloride channels	7819188
	Jmol (5)8.2(10)4	Scorpion2	KGX11_CENNO	1ne5  R F	A	42	0.902	Cnerg1, ergtx, ergtoxin	Solution nmr	Synthetic	Blocks the ether-a-go-go-related K+ channel	12650941
	Jmol (5)8.2(10)4	Scorpion2	KGX11_CENNO	1px9  R F	A	42	1.323	Ergtoxin	Solution nmr	Centruroides noxius	Blocks the ether-a-go-go-related K+ channel	15211519
	Jmol (2)10.2(6)4	Scorpion2	SCX5_BUTEU	1sis  R F	A	36	1.084	Scorpion insectotoxin i5a	Solution nmr	Mesobuthus eupeus	Short scorpion toxin	1815511

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Serine protease inhibitor1

24 three-dimensional structures of Serine protease inhibitor1 knottins

To display Sequence alignments OR Jmol Structural superimpositions of selected knottins:
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	Nomenclature	Family	SwissProt	PDBsum	Chain	Length	RMS	Descriptor	Experimental	Source	Function	PubMed
	Jmol (6)5.3(1)5	Serine protease inhibitor1	ITR1_CUCMA	1cti  R F	A	29	0.590	Trypsin inhibitor	Solution nmr	Cucurbita maxima	Trypsin inhibitor	2614837
	Jmol (6)5.3(1)4	Serine protease inhibitor1	ITR2_MOMCH	1f2s  R F	I	28	0.257	Trypsin inhibitor a	X-ray diffraction	Momordica charantia	Trypsin inhibitor	10524768
	Jmol (6)5.3(1)5	Serine protease inhibitor1	ITR2_ECBEL	1h9h  R F	I	36	0.241	Eeti-ii, trypsin inhibitor ii	X-ray diffraction	Synthetic ecballium elaterium	Trypsin inhibitor	16131759
	Jmol (6)5.3(1)5	Serine protease inhibitor1	ITR2_ECBEL	1h9i  R F	I	36	0.278	Eeti-ii, trypsin inhibitor ii	X-ray diffraction	Synthetic ecballium elaterium	Trypsin inhibitor	16131759
	Jmol (6)5.3(1)5[8]	Serine protease inhibitor1	ITR2_MOMCO	1ha9  R F	A	34	0.342	Mcoti-ii, trypsin inhibitor ii	Solution nmr	Momordica cochinchinensis	Trypsin inhibitor	11434766
	Jmol (6)5.3(1)5[8]	Serine protease inhibitor1	ITR2_MOMCO	1ib9  R F	A	34	0.548	Mcoti-i, trypsin inhibitor ii	Solution nmr	Momordica cochinchinensis	Trypsin inhibitor	11292835
	Jmol (6)5.3(1)5	Serine protease inhibitor1	ITR1_CUCMA	1lu0  R F	A	29	0.117	Cmti-i, trypsin inhibitor i	X-ray diffraction	Cucurbita maxima	Trypsin inhibitor	12198301
	Jmol (6)5.3(1)4	Serine protease inhibitor1	ITRA_MOMCH	1mct  R F	I	28	0.285	Trypsin inhibitor a	X-ray diffraction	Momordica charantia	Trypsin inhibitor	8445634
	Jmol (6)5.3(1)5	Serine protease inhibitor1	ELA1_PIG	1mcv  R F	I	28	0.139	Hybrid squash inhibitor hei-toe 1, hei-toe i	X-ray diffraction	Synthetic	Elastase inhibitor	12554935
	Jmol (6)5.3(1)5	Serine protease inhibitor1	ITR1_CUCMA	1ppe  R F	I	29	0.139	Trypsin inhibitor cmti-i	X-ray diffraction		Trypsin inhibitor	2914611
	Jmol (6)5.3(1)5	Serine protease inhibitor1	ITR2_ECBEL	1w7z  R F	A	31	0.219	Eeti-ii, trypsin inhibitor ii	X-ray diffraction	Ecballium elaterium	Trypsin inhibitor	16131759
	Jmol (6)5.3(1)5	Serine protease inhibitor1	ITR3_CUCPE	2btc  R F	I	29	0.000	Cpti-i, trypsi	X-ray diffraction	Cucurbita pepo	Trypsin inhibitor	10089404
	Jmol (6)5.3(1)5	Serine protease inhibitor1	ITR2_MOMCO	2c4b  R F	A	143	0.190	Barnase mcoeeti fusion	X-ray diffraction	Bacillus amyloliquefaciens, momordic	Trypsin inhibitor	16337652
	Jmol (6)5.3(1)5	Serine protease inhibitor1	ITR1_CUCMA	2cti  R F	A	29	0.285	Trypsin inhibitor	Solution nmr	Cucurbita maxima	Trypsin inhibitor	2614837
	Jmol (6)5.3(1)5	Serine protease inhibitor1	ITR2_ECBEL	2eti  R F	A	28	0.688	Trypsin inhibitor ii	Solution nmr	Ecballium elaterium	Trypsin inhibitor	2622910
	Jmol (6)5.3(1)5	Serine protease inhibitor1	ITR2_ECBEL	2it7  R F	A	28	0.246	Trypsin inhibitor ii, eeti-ii, trypsin inhibitor 2	Solution nmr	Synthetic	Trypsin inhibitor	_
	Jmol (6)5.3(1)5	Serine protease inhibitor1	ITR2_MOMCO	2it8  R F	A	30	0.185	Trypsin inhibitor ii, mcoti-ii, trypsin inhibitor 2	Solution nmr	Synthetic	Trypsin inhibitor	_
	Jmol (6)5.3(1)5	Serine protease inhibitor1	ITR2_ECBEL	2let  R F	A	28	0.732	Trypsin inhibitor ii	Solution nmr	Ecballium elaterium	Trypsin inhibitor with reduced affinity	8003965
	Jmol (6)5.3(1)5	Serine protease inhibitor1	ITR1_CUCMA	2sta  R F	I	29	0.188	Trypsi	X-ray diffraction	Cucurbita maxima	Trypsin inhibitor	10089404
	Jmol (6)5.3(1)5	Serine protease inhibitor1	ITR3_CUCPE	2stb  R F	I	29	0.190	Cpti-i, trypsi	X-ray diffraction	Cucurbita pepo	Trypsin inhibitor	10089404
	Jmol (6)5.3(1)5	Serine protease inhibitor1	ITR1_CUCMA	2v1v  R F	A	29	1.021	Trypsin inhibitor i, cmti-i, itd-i, trypsin inhibitor 1	Solution nmr	Synthetic cucurbita maxima	Trypsin inhibitor	10716179
	Jmol (6)5.3(1)5	Serine protease inhibitor1	ITR1_CUCMA	3cti  R F	A	29	0.326	Trypsin inhibitor	Solution nmr	Cucurbita maxima	Trypsin inhibitor	2051485
	Jmol (11)5.3(1)5	Serine protease inhibitor1	ITR2_ECBEL	2m7t  R F	A	33	0.409	Engineered Cystine Knot Protein 2.5D	Solution nmr	Synthetic construct	Target T0711 in CASP10	24318984
	Jmol (8)5.3(1)5	Serine protease inhibitor1	ITR2_MOMCO	2mt8  R F	A	39	0.428	MTAbl13 of grafted MCoTI-II	Solution nmr	Momordica cochinchinensis (Spiny bitter cucumber) (Muricia cochinchinensis)	Inhibits trypsin; probably participates in a plant defense mechanism.	26264857

To display Sequence alignments OR Jmol Structural superimpositions of selected knottins:
1 - Use the checkboxes to make selection or use the 'Select All' button
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Serine protease inhibitor2

0 three-dimensional structure of Serine protease inhibitor2 knottins

Serine protease inhibitor3

0 three-dimensional structure of Serine protease inhibitor3 knottins

Spider

73 three-dimensional structures of Spider knottins

To display Sequence alignments OR Jmol Structural superimpositions of selected knottins:
1 - Use the checkboxes to make selection or use the 'Select All' button
2 - Choose either a 1D Sequence alignment or a 3D Structural superimposition

	Nomenclature	Family	SwissProt	PDBsum	Chain	Length	RMS	Descriptor	Experimental	Source	Function	PubMed
	Jmol (7)6.0(4)10	Spider	TOG4B_AGEAP	1agg  R F	A	48	0.951	Omega-aga-iv, omega-agatoxin-ivb	Solution nmr	Agelenopsis aperta	Antagonist of P-type calcium channel	7703698
	Jmol (6)5.0(3)13	Spider	TOT1A_HADVE	1axh  R F	A	37	0.603	Actx-hvi, atracotoxin-hvi	Solution nmr	Hadronyche versuta	Inhibits insect calcium channel currents	9228949
	Jmol (6)5.0(4)6	Spider	TXHN1_GRARO	1d1h  R F	A	35	0.625	Hanatoxin type 1	Solution nmr	Grammostola rosea	Modifier of potassium channels	10731427
	Jmol (6)5.0(4)9	Spider	TJT1C_HADVE	1dl0  R F	A	37	0.794	J-atracotoxin-hv1c	Solution nmr	Synthetic	Inhibits insect potassium channels	10881200
	Jmol (6)6.0(4)9	Spider	TXMG1_AGEAP	1eit  R F	A	37	0.754	Mu-aga-, mu-agatoxin-i	Solution nmr	Agelenopsis aperta	Modify kinetics of insect sodium channels	8608119
	Jmol (6)5.0(4)3	Spider	TXHP2_HETVE	1emx  R F	A	30	1.078	Hptx2, heteropodatoxin 2	Solution nmr	Heteropoda venatoria	Bolcks kv4.2 potassium channel	11152117
	Jmol (6)5.0(5)4	Spider	TOT2A_HADVE	1g9p  R F	A	45	0.427	Omega-atracotoxin-hv2a	Solution nmr	Hadronyche versuta	Blocks insect calcium channels	11522785
	Jmol (6)5.0(5)4	Spider	TOT2A_HADVE	1hp3  R F	A	32	0.434	Ct-hv2a, omega-atracotoxin-hv2a	Solution nmr	Synthetic	Blocks insect calcium channels	11522785
	Jmol (6)5.0(3)4	Spider	TOT1A_HADVE	1hvw  R F	A	25	0.699	Omega-actx-hv1a, omega-atracotoxin-hv1a	Solution nmr	Synthetic	Inhibits insect calcium channel currents	11313356
	Jmol (7)6.0(4)10	Spider	TOG4A_AGEAP	1iva  R F	A	48	0.905	Omega-agatoxin-iva	Solution nmr	Agelenopsis aperta	Blocks P-type calcium channels	7773772
	Jmol (6)5.0(4)8	Spider	WGRTX_GRARO	1koz  R F	A	36	0.878	Omega-grammotoxin sia, voltage-dependent channel inhibitor	Solution nmr	Synthetic	Gating modifier of P/Q and N-type calcium channels	12162963
	Jmol (6)7.0(4)9	Spider	TXMO_HADIN	1kqh  R F	A	38	0.573	Actx-hi:ob4219	Solution nmr	Hadronyche infensa	Inhibits sodium channels of insects	11876637
	Jmol (6)7.0(4)9	Spider	TXMO_HADIN	1kqi  R F	A	38	0.645	Actx-hi:ob4219	Solution nmr	Hadronyche infensa	Inhibits sodium channels of insects	11876637
	Jmol (6)5.0(4)6	Spider	TX1_STRGF	1la4  R F	A	34	0.572	Voltage-gated potassium channel blocker, sgtx1	Solution nmr	Synthetic	Voltage-gated potassium channel blocker	14744131
	Jmol (6)6.0(4)9	Spider	TXP1_PSACA	1lmm  R F	A	40	0.742	Pctx1, psalmotoxin 1	Solution nmr	Psalmopoeus cambridgei	Specific blocker of ASIC1A Na+ channel	12824480
	Jmol (6)6.0(5)6	Spider	MTX4_GRARO	1lu8  R F	A	35	0.592	Gsmtx-4, venom toxin peptide mtx4	Solution nmr	Synthetic	Blocks mechanosensitive ion channels	_
	Jmol (6)5.0(4)3	Spider	MTX2_GRARO	1lup  R F	A	31	1.243	Gsmtx2	Solution nmr	Grammostola rosea	inhibits mechanosensitive ion channels	12082099
	Jmol (6)6.0(6)6	Spider	TXH4_HAPSC	1mb6  R F	A	35	0.619	Huwentoxin-iv	Solution nmr	Ornithoctonus huwena	Acts on tetrodotoxin-sensitive sodium channels	12228241
	Jmol (6)6.0(4)6	Spider	H1A01_HAPHA	1nix  R F	A	34	0.453	Hainantoxin-i	Solution nmr	Ornithoctonus hainana	Binds and blocks insect sodium channels	14675784
	Jmol (6)6.0(6)6	Spider	H4A01_HAPHA	1niy  R F	A	36	0.489	Hntx-i, hainantoxin-iv	Solution nmr	Ornithoctonus hainana	Inhibits mammal TTX-sensitive sodium currents	15201273
	Jmol (7)6.0(4)10	Spider	TOG4A_AGEAP	1oav  R F	A	48	0.641	Omega-agatoxin iva	Solution nmr	Agelenopsis aperta	Blocks P-type calcium channel	7623383
	Jmol (7)6.0(4)10	Spider	TOG4A_AGEAP	1oaw  R F	A	48	0.627	Omega-agatoxin iva	Solution nmr	Agelenopsis aperta	Blocks P-type calcium channel	7623383
	Jmol (7)6.0(4)10	Spider	TOG4B_AGEAP	1oma  R F	A	48	1.059	Omega-aga-ivb	Solution nmr	Agelenopsis aperta	Antagonist of P-type calcium channels	8241166
	Jmol (7)6.0(4)10	Spider	TOG4B_AGEAP	1omb  R F	A	48	0.795	Omega-aga-ivb	Solution nmr	Agelenopsis aperta	Antagonist of P-type calcium channels	8241166
	Jmol (6)5.0(4)10	Spider	TXDT1_ATRRO	1qdp  R F	A	42	0.601	Robustoxin	Solution nmr	Atrax robustus	Slows inactivation of tetrodotoxin-sensitive sodium channels	9428632
	Jmol (6)6.0(4)6	Spider	TXH1_HAPSC	1qk6  R F	A	33	0.633	Huwentoxin-i	Solution nmr	Selenocosmia huwena	Binds to the nicotinic acetylcholine receptor	9263120
	Jmol (4)5.0(4)6	Spider	TXL1_HAPSC	1qk7  R F	A	32	0.462	Selenocosmia huwena lectin-i	Solution nmr	Selenocosmia huwena	haemagglutination	10524779
	Jmol (6)6.0(6)6	Spider	H4A01_HAPHA	1ryg  R F	A	36	0.501	Hntx-iv, hainantoxin-iv	Solution nmr	Synthetic	Sodium channels inhibitor	15201273
	Jmol (6)6.0(6)6	Spider	H4A01_HAPHA	1ryv  R F	A	36	0.451	Hntx-iv, hainantoxin-iv	Solution nmr	Synthetic	Sodium channels inhibitor	15201273
	Jmol (6)5.0(4)6	Spider	VSTX1_GRARO	1s6x  R F	A	34	0.429	Vstx, gating modifier toxin, kvap channel	Solution nmr	Synthetic	Gating modifier toxin	15835890
	Jmol (6)6.0(5)6	Spider	MTX4_GRARO	1tyk  R F	A	34	0.728	Mtx, toxin gsmtx-4	Solution nmr	Grammostola rosea	Blocks mechanosensitive ion channels	12082099
	Jmol (6)8.0(2)4	Spider	_	1v5a  R F	A	28	0.888	Covalitoxin-i	Solution nmr	Synthetic	_	_
	Jmol (6)5.0(4)3	Spider	TXP1_PARSR	1v7f  R F	A	30	0.885	Patx1, phrixotoxin 1	Solution nmr	Synthetic	Specifically blocks Kv4.3 and Kv4.2 channels	15096626
	Jmol (6)7.0(4)9	Spider	TXDP1_PIRLC	1v90  R F	A	38	1.156	Delta-paluit, delta-palutoxin it1	Solution nmr	Paracoelotes luctuosus	Inhibits the inactivation of sodium activated channels on in	15726637
	Jmol (6)7.0(4)9	Spider	TXDP2_PIRLC	1v91  R F	A	38	0.866	Delta-paluit, delta-palutoxin it2	Solution nmr	Paracoelotes luctuosus	Inhibits the inactivation of sodium activated channels on in	15726637
	Jmol (6)5.0(4)10	Spider	TXDT1_HADVE	1vtx  R F	A	42	0.769	Versutoxi, delta-atracotoxin-hv1	Solution nmr	Hadronyche versuta	Slows inactivation of sodium channels	9384567
	Jmol (6)6.0(4)4	Spider	TXP7_APOSC	1wqb  R F	A	32	0.653	Paralytic peptide vii, pp vii, aptotoxin vii	Solution nmr	Synthetic	Paralytic and lethal to lepidopteran larvae	_
	Jmol (6)8.0(4)4	Spider	TXFK1_PSACA	1x5v  R F	A	34	0.957	Pcfk1	Solution nmr	Psalmopoeus cambridgei	Strong antiplasmodial activity	16452619
	Jmol (6)8.0(2)4	Spider	TXH10_HAPSC	1y29  R F	A	28	0.941	Huwentoxin-x	Solution nmr	Synthetic	Blocks N-type, but not L-type, calcium channels	16439354
	Jmol (6)6.0(4)6	Spider	JZT7A_CHIJI	1zjq  R F	A	34	0.835	Jingzhaotoxin-vii	Solution nmr	Chilobrachys jingzhao	Toxin	_
	Jmol (6)5.0(4)6	Spider	JZ11A_CHIJI	2a2v  R F	A	34	0.473	Jingzhaotoxin-xi	Solution nmr	Chilobrachys jingzhao	Toxin	17176080
	Jmol (6)6.0(4)6	Spider	JZT7A_CHIJI	2aap  R F	A	34	0.692	Jingzhaotoxin-vii	Solution nmr	Chilobrachys jingzhao	Toxin	_
	Jmol (6)7.0(4)9	Spider	TXAG_ALLOP	2e2s  R F	A	36	0.775	Agelenin	Solution nmr	Allagelena opulenta	Insecticid, blocks the presynaptic calcium channel	17644092
	Jmol (6)5.0(4)4	Spider	TXMG5_MACGS	2gx1  R F	A	29	1.004	Neurotoxin magi-5	Solution nmr	Synthetic	Binds specifically to receptor site 4 on mammalian voltage-g	17148449
	Jmol (6)6.0(4)13	Spider	_	2h1z  R F	A	39	0.507	Hybrid atracotoxin	Solution nmr	Hadronyche versuta	?	_
	Jmol (6)6.0(4)6	Spider	JZTX3_CHIJI	2i1t  R F	A	36	1.000	Jingzhaotoxin-iii, jztx-ii, jingzhaotoxin-3	Solution nmr	Chilobrachys jingzhao	Inhibits voltage-gated sodium channels in rat cardiac myocyt	17481690
	Jmol (6)6.0(4)6	Spider	H3A01_HAPHA	2jtb  R F	A	33	0.852	Hainantoxin-iii, hntx-ii, hainantoxin-3	Solution nmr	Ornithoctonus hainana	Acts on mammal tetrodotoxin-sensitive voltage-gated sodium c	_
	Jmol (6)4.0(4)10	Spider	TXPR1_GEOA2	2kgu  R F	A	35	0.481	Purotoxin-1	Solution nmr	Geolycosa	Inhibits P2X3 receptors	20437566
	Jmol (6)6.0(4)9	Spider	TXP1_PSACA	2kni  R F	A	41	0.578	Pctx1, psalmotoxin-1	Solution nmr	Psalmopoeus cambridgei	Blocks the H+-gated sodium channel ASIC1a/ACCN2	_
	Jmol (6)5.0(4)10	Spider	TXMG4_MACGS	2roo  R F	A	43	0.671	Delta-hexatoxin-mg1a	Solution nmr	Synthetic	Blocks voltage-gated sodium channels	19592486
	Jmol (6)6.0(4)6	Spider	TXG1E_CHIJI	2wh9  R F	A	36	0.813	Gxtx-1e, gxtx1, guangxitoxin-1egxtx-1e	Solution nmr	Synthetic plesiophrictus guangxiensis	Gating modifier of Kv2.1/KCNB1, Kv2.2/KCNB2 and Kv4.3/KCND3	20509680
	Jmol (6)5.0(3)6	Spider	TXP3_APOSC	2m36  R F	A	38	0.704	Aps III, insecticidal spider-venom peptide	Solution nmr	Aptostichus schlingeri	Blocks insect voltage-gated sodium channels	23473802
	Jmol (6)6.0(8)15	Spider	TXPR2_GEOA2	2mdn  R F	A	64	0.689	Purotoxin-2	Solution nmr	Geolycosa sp. a267tdls2-kzarna	-	-
	Jmol (6)7.0(2)19	Spider	SFI1_SEGFL	2mf3  R F	A	47	0.917	SFI1, insecticidal spider toxin	Solution nmr	Segestria florentina	Blocks the pore of insect voltage-gated sodium channels via a large β-hairpin loop	25559770
	Jmol (6)4.0(13)13	Spider	TXI92_DIGCA	2mi5  R F	A	57	0.984	Mu-diguetoxin-Dc1a (Mu-DGTX-Dc1a)	Solution nmr	Diguetia canities	Interacts with the domain II voltage sensor	25014760
	Jmol (6)6.0(6)6	Spider	A0A0J9X1W9_9ARAC	2mpq  R F	A	36	0.606	Sodium channel toxin Hd1a	Solution nmr	Haplopelma	Modulator of the analgesic target NaV 1.7	25754331
	Jmol (6)7.0(4)10	Spider	TXHM3_HERML	2mqu  R F	A	35	0.606	Neurotoxin Hm-3	Solution nmr	Heriaeus melloteei	Sodium channel activation inhibitor, insecticidal peptide toxin	25352595
	Jmol (6)6.0(4)6	Spider	A0A0M3KKS8_9ARAC	2mt7  R F	A	35	0.470	Spider-venom peptide Hs1a	Solution nmr	Hysterocrates	-	-
	Jmol (6)6.0(4)6	Spider	HPR3_THRPR	2mxm  R F	A	33	0.581	Mu-theraphotoxin-Tp1a	Solution nmr	Thrixopelma pruriens	Inhibits voltage-gated sodium channels without significantly altering the voltage dependence of activation or inactivation	25979003
	Jmol (6)11.0(3)12	Spider	A0A0G3F8Z3_9ARAC	2myh  R F	A	41	0.537	Omega-Tbo-IT1	Solution nmr	Tibellus oblongus	Inhibitor of Insect Calcium Channels	26611444
	Jmol (6)4.0(4)8	Spider	TXAG4_AGEOR	2n6n  R F	A	32	0.850	U4-agatoxin-Ao1a	Solution nmr	Agelena orientalis	Ion channel inhibitor activity	-
	Jmol (6)5.0(11)14	Spider	A0A1D5B342_HADIN	2n6r  R F	A	76	0.691	U4-hexatoxin-Hi1a	Solution nmr	Hadronyche infensa	-	-
	Jmol (6)6.0(14)26	Spider	TP1A_HADIN	2n8f  R F	A	76	0.602	Pi-hexatoxin-Hi1a	Solution nmr	Hadronyche infensa	Potently and selectively inhibits ASIC1a	-
	Jmol (6)6.0(4)6	Spider	TX1_PSARE	5i1x  R F	A	36	0.711	F8A mutant of beta-TRTX-Pre1a	Solution nmr	Psalmopoeus reduncus	Gating-modifier toxin that both inhibits the peak current of human Nav1.1/SCN1A, rat Nav1.2/SCN2A, human Nav1.6/SCN8A, and human Nav1.7/SCN9A	-
	Jmol (6)6.0(4)6	Spider	TX1_PSARE	5i2p  R F	A	36	0.620	W7A mutant of mu-TRTX-Pre1a	Solution nmr	Psalmopoeus reduncus	Gating-modifier toxin that both inhibits the peak current of human Nav1.1/SCN1A, rat Nav1.2/SCN2A, human Nav1.6/SCN8A, and human Nav1.7/SCN9A	-
	Jmol (6)5.0(4)3	Spider	TXPR2_THRPR	5tcz  R F	A	32	1.226	Beta/omega-theraphotoxin-Tp2a	Solution nmr	Thrixopelma pruriens	Blocks both tetrodotoxin-sensitive and tetrodotoxin-resistant human voltage-gated sodium channels by shifting the voltage dependence of channel activation to more positive potentials.	28045073
	Jmol (12)12.0(4)7	Spider	DKTX_HAPSC	5irx  R F	E	75	0.845	Tau-theraphotoxin-Hs1a	Electron microscopy	Haplopelma schmidti (Chinese bird spider) (Ornithoctonus huwenum)	Selectively activates mammalian TRPV1, or capsaicin receptor, a nonselective cation channel expressed by sensory neurons of the pain pathway.	27281200
	Jmol (6)5.0(4)7	Spider	DKTX_HAPSC	2naj  R F	A	33	1.325	Tau-theraphotoxin-Hs1a, Fragment: K2 domain, UNP residues 43-75	Solution nmr	Haplopelma schmidti (Chinese bird spider) (Ornithoctonus huwenum)	Selectively activates mammalian TRPV1, or capsaicin receptor, a nonselective cation channel expressed by sensory neurons of the pain pathway.	26880553
	Jmol (6)5.0(6)7	Spider	DKTX_HAPSC	2n9z  R F	A	42	0.895	Tau-theraphotoxin-Hs1a, Fragment: K1 domain, UNP residues 1-42	Solution nmr	Haplopelma schmidti (Chinese bird spider) (Ornithoctonus huwenum)	Selectively activates mammalian TRPV1, or capsaicin receptor, a nonselective cation channel expressed by sensory neurons of the pain pathway.	26880553
	Jmol (6)5.0(4)15	Spider	SPN1A_OXYTA	2n86  R F	A	59	-	Spiderine-1a, Fragment: UNP residues 108-166	Solution nmr	Oxyopes takobius	Has antimicrobial, insecticidal, cytolytic and cytotoxic activity.	-
	Jmol (6)9.0(4)4	Spider	TX1_SELPU	2ll1  R F	A	33	0.640	U1-TRTX-Sp1a	Solution nmr	Selenotypus plumipes (Australian featherleg tarantula)	Probable ion channel inhibitor. Shows insecticidal activity. Acts synergistically with the neonicotinoid insecticide imidacloprid.	-
	Jmol (5)4.0(13)9	Spider	Q4PN35_IXOSC	2ndi  R F	A	46	-	Putative secreted salivary protein	Solution nmr	Ixodes scapularis (Black-legged tick) (Deer tick)	Selective inhibitor of the Nav1.7 channel	27407029
	Jmol (6)6.0(4)6	Spider	JZT7A_CHIGU	1zjq  R F	A	34	0.796	U1-theraphotoxin-Cg1a 1	Solution nmr	Chilobrachys guangxiensis	Probable ion channel inhibitor.	-

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Sponge

4 three-dimensional structure of Sponge knottins

To display Sequence alignments OR Jmol Structural superimpositions of selected knottins:
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	Nomenclature	Family	SwissProt	PDBsum	Chain	Length	RMS	Descriptor	Experimental	Source	Function	PubMed
	Jmol (6)6.0(6)8	Sponge	I1SB10_9METZ	3q8j  R F	A	37	0.697	Asteropsin A	Solution nmr	Asteropus sp.	Enhances Ca2+ influx in murine cerebrocortical neuron cells	-
	Jmol (6)6.0(6)8	Sponge	I1SB10_9METZ	2lqa  R F	A	37	0.761	Asteropsin A	Solution nmr	Asteropus sp.	Enhances Ca2+ influx in murine cerebrocortical neuron cells	23201194
	Jmol (6)6.0(4)8	Sponge	I1SB10_9METZ	2m3j  R F	A	33	0.813	Asteropsin E	Solution nmr	Asteropus	-	-
	Jmol (6)6.0(4)8	Sponge	A0A1A9T938_9METZ	2n2g  R F	A	33	0.743	Asteropsin_F	Solution nmr	Asteropus	-	-

To display Sequence alignments OR Jmol Structural superimpositions of selected knottins:
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Trematoda

0 three-dimensional structure of Trematoda knottins

Trichoplax

0 three-dimensional structure of Trichoplax knottins

Virus1

2 three-dimensional structures of Virus1 knottins

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	Nomenclature	Family	SwissProt	PDBsum	Chain	Length	RMS	Descriptor	Experimental	Source	Function	PubMed
	Jmol (6)6.0(16)7	Virus1	Q89632_CSIV	1xi7  R F	A	61	0.931	Vhv1.1 protein, cysteine-rich omega-conotoxin homolog vhv1.1	Solution nmr	Campoletis sonorensis ichnovirus	_	11724552
	Jmol (6)6.0(16)7	Virus1	Q89632_CSIV	1xj1  R F	A	61	0.823	Vhv1.1 protein, cysteine-rich omega-conotoxin homolog vhv1.1	Solution nmr	Campoletis sonorensis ichnovirus	_	11724552

To display Sequence alignments OR Jmol Structural superimpositions of selected knottins:
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Virus2

0 three-dimensional structure of Virus2 knottins

Water flea

0 three-dimensional structure of Water flea knottins