Anthelmintic activity
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Cyclotides possess anthelmintic activity
- Several Kalata and cycloviolacin
peptides were shown to display significant activity in inhibiting larvae development and adult motility
of Haemonchus contortus and Trichostrongylus colubriformis larvae, two important gastrointestinal
nematode parasites of sheep.
The activity displays no chiral selectivity and appears to be related to clustered basic residues
suggesting that membrane interaction rather than interaction with a receptor is involved in the
cyclotide anthelmintic activity
[Colgrave et al., 2008].
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