Knottins display a variety of biological functions


  • ‣ Some knottins are thought to perform their action via interaction with a receptor.
  • ‣ This has led several authors to use the slightly restrictive name "Inhibitor Cystine Knot" (ICK)
  • ‣ Different activities are located on different parts of the molecules, and almost all Knottin loops have been implied in one ore more function.
  • ‣ The major known biological functions exerted by Knottins are briefly outlined below.
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Analgesics

Anthelmintic

Anti-ED

Antimalarial

Antimicrobials

Antitumors

Protease inhibitors

Toxins

Insecticids

Others

Antimalarial activity

Toxins from the venom of the tarantula Psalmopoeus cambridgei display strong antiplasmodial activity