Antitumors
|
Antitumor activities have
been shown for PCI and cyclotides
- The Potato Carboxypeptidase inhibitor
PCI is an antagonist of
human EGF and inhibits tumor cell growth
[Blanco-Aparicio et al., 1998
]
- The cyclotides varv A, varv F,
and cycloviolacin O2 display
cytotoxicity for several human tumor cell lines [Lindholm
et al., 2002]. The activity profiles
differed significantly from those of antitumor drugs in clinical
use, suggesting a new mode of action for these cyclotides.
- Cycloviolacin O2 Disrupts Lipid Membranes.
Cytotoxic, antimicrobial, hemolytic,
and insecticidal effects are likely all connected to membrane disruption.
[Svangard et al., 2007
].
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