Anti Erectile Dysfunction (ED)
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A spider toxin induces penile erection in rats
- The spider toxin Tx2-6 was shown to induce
and facilitate the ganglionic-stimulated penile erection in rats. It also displayed a potentiation
effect on penile erection of animals presenting severe erectile dysfunction such as the
deoxycorticosterone-acetate-salt hypertensive rats. The potentiating effect of Tx2-6 on erection seems
to be mediated by relaxation of the vasculature and smooth muscle in the corpus cavernosum induced by
the release of NO
[Nunes et al., 2008].
- Also note that the agouti-related and the agouti-signaling
proteins act on the melanocortin system that is involved in sexual function.
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