The KNOTTIN database

‣ Some knottins are thought to perform their action via interaction with a receptor.
‣ This has led several authors to use the slightly restrictive name "Inhibitor Cystine Knot" (ICK)
‣ Different activities are located on different parts of the molecules, and almost all Knottin loops have been implied in one ore more function.
‣ The major known biological functions exerted by Knottins are briefly outlined below.

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Antimicrobials
Several knottins display antimicrobial activities • A review about antimicrobial activity of plant peptides, including some knottins [ Tam et al., 2015 ] • In Bemisia tabaci, three knottin-like antimicrobial peptide genes are activated in response to the pathogen Pseudomonas aeruginosa [ Zhang et al., 2014 ] *Cyclotides from the butterfly pea (Clitoria ternatea)* [Nguyen et al., 2016] *PAFP-s* [Shao et al., 1999] *Several cyclotides* [Tam et al., 1999] *Tachystatin* [Osaki et al., 1999]
Source	Knottin	PDB ID	Inhibits growth of
			gram +	gram -	fungi
Plant	PAFPS	1DKC			+
Plant	Kalata B1	1KAL 1K48 1NB1	+
Plant	Circulin A	1BH4	+
Plant	Circulin B		+	+
Plant	Cyclopsychotride		+	+	+

Crab	Tachystatin	1CIX	+	+	+